Effect of Early Administration of TXA in Adult Hip Fractures

Description

This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center. It is well established in the orthopedic literature that tranexamic acid (TXA) decreases blood loss and need for postoperative blood transfusion in hip fracture patients as well as total joint arthroplasty patients. A typical dosing pattern, and the dosing pattern employed at our institution, is 1 gram IV infused prior to incision followed by 1 gram IV infused at the time of wound closure.

Conditions

Postoperative Blood Loss

Study Overview

Study Details

Study overview

This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center. It is well established in the orthopedic literature that tranexamic acid (TXA) decreases blood loss and need for postoperative blood transfusion in hip fracture patients as well as total joint arthroplasty patients. A typical dosing pattern, and the dosing pattern employed at our institution, is 1 gram IV infused prior to incision followed by 1 gram IV infused at the time of wound closure.

Does Early Administration of Tranexamic Acid Decrease Perioperative Blood Loss in Addition to Intraoperative Tranexamic Acid for Hip Fracture Patients?

Effect of Early Administration of TXA in Adult Hip Fractures

Condition
Postoperative Blood Loss
Intervention / Treatment

-

Contacts and Locations

Grand Blanc

Ascension Genesys Hospital, Grand Blanc, Michigan, United States, 48439

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 1. All adult (18 years old or older) hip fracture patients presenting with an acute hip fracture and undergoing operative fixation
  • 1. Polytrauma patients
  • 2. Previous operation on the ipsilateral hip
  • 3. Patients with coagulopathies (Factor V Leiden, Sickle Cell Anemia, Etc.)
  • 4. Patients with \< 6-month history of thromboembolic event (DVT/PE), Stroke, Cardiac Stents, or Myocardial Infarction (MI)
  • 5. History of seizure disorder
  • 6. Patients on birth control
  • 7. Pregnant Women
  • 8. Prisoners
  • 9. Active thromboembolic disease (DVT/PE, MI, Stroke)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ascension Health,

Study Record Dates

2022-07-01