RECRUITING

Tdcs And cogNitive traininG cOmbined for AUD (TANGO)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overarching goal of this project is to expand the traditional expertise in non-invasive neuromodulation at the University of Minnesota towards developing novel paired-neuromodulation approaches using transcranial direct current stimulation (tDCS) for new treatments for alcohol use disorder (AUD) that support long-term abstinence. This study will allow the investigators to discern whether the pairing of dorsolateral prefrontal cortex (DLPFC) stimulation and cognitive training can lead to improved treatment outcomes as it pertains to executive functioning and maintenance of abstinence. This paired-neuromodulation approach can potentially be used as a therapeutic intervention to decrease relapse probability in addiction. The long-term goal is to develop new addiction treatments that support long-term abstinence. The exploratory goal of this research is to associate genotypes and epigenetic changes with variations in intervention response and clinical outcome. Individual differences in baseline genetic profiles or epigenetic changes over the course of treatment could be associated with treatment response variability.

Official Title

Tdcs And cogNitive traininG cOmbined for AUD (TANGO)

Quick Facts

Study Start:2022-03-03
Study Completion:2025-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05062369

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Meet the Diagnostic and Statistical Manual of Mental Disorders diagnostic criteria for AUD
  2. * Abstinent from alcohol use
  3. * Must have the intention to remain in the Lodging Plus program until the end of the intervention portion of the study.
  1. * Any medical condition or treatment with neurological sequelae (i.e. stroke, tumor, loss of consciousness\>30 min, HIV)
  2. * A head injury resulting in a skull fracture or a loss of consciousness exceeding 30 minutes (i.e., moderate or severe TBI)
  3. * Any contraindications for tDCS or MRI scanning (tDCS contraindication: history of seizures; MRI contraindications; metal implants, pacemakers or any other implanted electrical device, injury with metal, braces, dental implants, non-removable body piercings, pregnancy, breathing or moving disorder)
  4. * Any primary psychotic disorder (e.g. schizophrenia, schizoaffective disorder); Participants with other treated and stable psychiatric disorders will be included
  5. * Presence of a condition that would render study measures difficult or impossible to administer or interpret
  6. * Primary current substance use disorder diagnosis on a substance other than alcohol except for caffeine or nicotine
  7. * Clinical evidence for Wernicke-Korsakoff syndrome
  8. * Left-handedness
  9. * Entrance to the treatment program under a court mandate

Contacts and Locations

Study Contact

Jazmin Camchong, PhD
CONTACT
(612) 842-8704
camch002@umn.edu
Clarista Berg
CONTACT
berg2920@umn.edu

Principal Investigator

Jazmin Camchong, PhD
PRINCIPAL_INVESTIGATOR
Univeristy of Minnesota Department of Psychiatry & Behavioral Sciences

Study Locations (Sites)

University of Minnesota
Minneapolis, Minnesota, 55414
United States

Collaborators and Investigators

Sponsor: University of Minnesota

  • Jazmin Camchong, PhD, PRINCIPAL_INVESTIGATOR, Univeristy of Minnesota Department of Psychiatry & Behavioral Sciences

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-03-03
Study Completion Date2025-09

Study Record Updates

Study Start Date2022-03-03
Study Completion Date2025-09

Terms related to this study

Additional Relevant MeSH Terms

  • Alcohol Use Disorder
  • Addiction