Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness

Description

Millions of Americans suffer from high blood pressure, diabetes, strokes and motor vehicle accidents due to ineffective treatment of obstructive sleep apnea (OSA). Our preliminary data suggest that physiological causes of OSA such as easy arousability (low arousal threshold) or unstable breathing control (high loop gain) may influence effectiveness of OSA's most common treatment, continuous positive airway pressure (CPAP). The NICE-PAP study will examine how the physiologic traits that cause OSA in each individual impact CPAP effectiveness and can lead to personalized OSA treatments that improve patient lives.

Conditions

Obstructive Sleep Apnea

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Study Overview

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Study Details

Study overview

Millions of Americans suffer from high blood pressure, diabetes, strokes and motor vehicle accidents due to ineffective treatment of obstructive sleep apnea (OSA). Our preliminary data suggest that physiological causes of OSA such as easy arousability (low arousal threshold) or unstable breathing control (high loop gain) may influence effectiveness of OSA's most common treatment, continuous positive airway pressure (CPAP). The NICE-PAP study will examine how the physiologic traits that cause OSA in each individual impact CPAP effectiveness and can lead to personalized OSA treatments that improve patient lives.

Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness: NICEPAP Study Prospective Cohort

Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness

Condition
Obstructive Sleep Apnea
Intervention / Treatment

-

Contacts and Locations

North Haven

Yale New Haven Hospital Sleep Center, North Haven, Connecticut, United States, 06473

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age of \>18 years
  • 2. Newly diagnosed OSA naïve to CPAP
  • 3. Apnea hypopnea index (AHI) ≥5/hr on in-laboratory polysomnography or home sleep test acquired and scored using standard criteria(59)
  • 4. Referred for CPAP adherence management at Yale New Haven Hospital Sleep Center
  • 1. Need for supplemental oxygen
  • 2. Central apnea index comprising \>50% of the AHI
  • 3. Treatment recommendation with another modality (e.g., Bilevel PAP, Adaptive Servo-Ventilation, Automatic Volume Pressure Assured Pressure Support)
  • 4. A referral for a sleep disorder other than OSA (i.e., narcolepsy, sleep related movement disorder, circadian rhythm sleep-wake disorder)
  • 5. Prior CPAP or Auto-CPAP use over the past 3 years
  • 6. Unstable medical or mental health condition (e.g., decompensated heart failure, end-stage chronic obstructive pulmonary disease, end stage renal disease, psychosis)
  • 7. Inability to participate in the informed consent process (e.g., cognitive impairment)
  • 8. Pregnancy
  • 9. Non-English language use as only means of communication (because the research budget does not provide adequate resources to ensure that the needs of non-English speaking patients can be adequately addressed)

Ages Eligible for Study

19 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Yale University,

Andrey Zinchuk, MD, MHS, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2025-03-31