A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD

Description

The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.

Conditions

Depression, Pain, Cognitive Impairment

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Study Overview

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Study Details

Study overview

The purpose of the study is to examine the effect of Problem Adaptation Therapy for Pain (PATH-Pain) on cognitive functioning, depression and pain-related disability in 100 older adults with cognitive impairment, chronic pain, and depression. The study will test if PATH-Pain has better cognitive, affective, and functional outcomes than Attention Control Usual Care.

PATH-Pain: A Primary Care-Based Psychosocial Intervention To Improve Cognitive and Depression Outcomes in Older Adults With MCI and Early Stage AD

A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD

Condition
Depression
Intervention / Treatment

-

Contacts and Locations

White Plains

Weill Cornell Medicine, White Plains, New York, United States, 10502

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥ 60 years old
  • * MCI or early stage probable or possible AD diagnosis (as defined by Albert et al or McKhann et al) al). Patients will have at least mild cognitive deficits defined by 16 ≤ MoCA ≤ 25.
  • * Montgomery Asberg Depression Rating Scale (MADRS)\[55\] total ≥ 5, which reflects at least some mild depressive symptoms.
  • * Participants will be off antidepressants, cholinesterase inhibitors or memantine or on a stable dosage for at least 12 weeks.
  • * Chronic pain (neuropathic, nociceptive or mixed disorders): presence of pain on most days for at least 3 months and average pain intensity score \>=4.
  • * Clinical Dementia Rating 0.5 ≤ (CDR) ≤ 1.
  • * Participant will have capacity to consent.
  • * Participation of a study partner (e.g. caregiver/family member/significant other) is required.
  • * Deemed to have a significant suicide risk as assessed by site PI and clinical team.
  • * Deemed too unstable medically or neurologically to safely enroll in a research trial.
  • * Deemed too psychiatrically unstable to safely enroll in randomized trial of psychotherapy.
  • * Requiring psychiatric hospitalization at baseline for safety.
  • * Lack of English fluency.

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Weill Medical College of Cornell University,

Dimitris Kiosses, PhD, PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

Mannigton C Reid, MD, PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

Lisa Ravdin, PhD, PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

Study Record Dates

2027-07-31