Locomotor Recovery and Compensation Post-stroke (LRC)

Description

The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke. In addition, we will also investigate the extent to which measures of recovery and compensation are malleable and can be altered with specific interventions in both the early and late stages post-stroke. Delineation of the time course of development and magnitude of patterns of recovery and compensation should result in alternative predictive "rules' regarding how patients early post-stroke could recovery functional and neurological function.

Conditions

Stroke

Study Overview

Study Details

Study overview

The proposed research will characterize of the time course of neurological and locomotor recovery as well as development of compensatory strategies throughout sub-acute and chronic phases post stroke. In addition, we will also investigate the extent to which measures of recovery and compensation are malleable and can be altered with specific interventions in both the early and late stages post-stroke. Delineation of the time course of development and magnitude of patterns of recovery and compensation should result in alternative predictive "rules' regarding how patients early post-stroke could recovery functional and neurological function.

Locomotor Recovery and Compensation Post-stroke (LRC)

Locomotor Recovery and Compensation Post-stroke (LRC)

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Indianapolis

Rehabilitation Hospital of Indiana, Indianapolis, Indiana, United States, 46254

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * individuals early post-stroke (\<15-30 days)
  • * first ever stroke
  • * unilateral hemiparesis
  • * currently receiving inpatient rehabilitation
  • * ability to follow 1-step commands
  • * provision of informed consent
  • * medical clearance from the rehabilitation physician to participate. \\
  • * uncontrolled cardiovascular, metabolic or respiratory disease that limits exercise participation (e.g., congestive heart failure, resting blood pressure \> 200/110 mmHg, uncontrolled diabetes, end-stage renal disease)
  • * absolute criteria for termination of exercise testing during initial and repeated ECG testing during graded exercise testing using ACSM guidelines .
  • * other orthopedic or neurological disorder that limited walking prior to stroke

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Indiana University,

Thomas G Hornby, PRINCIPAL_INVESTIGATOR, Indiana University School of Medicine

Study Record Dates

2026-02-28