Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism

Description

The purpose of the study is to provide access to 18F-DOPA PET to patients at Washington University and assess the utility of 18F-DOPA PET/MRI as a preoperative tool to detect and localize focal lesions in the pancreas that are causing hyperinsulinism.

Conditions

Hyperinsulinism

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of the study is to provide access to 18F-DOPA PET to patients at Washington University and assess the utility of 18F-DOPA PET/MRI as a preoperative tool to detect and localize focal lesions in the pancreas that are causing hyperinsulinism.

Use of18F-DOPA PET/MRI for the Detection and Localization of Focal Forms of Hyperinsulinism

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism

Condition
Hyperinsulinism
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Washington University, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patients with confirmed hyperinsulinemic hypoglycemia, diagnosed by elevated insulin levels during hypoglycemia and/or response to glucagon stimulation.
  • 2. Subjects who failed pharmacological therapy with diazoxide or octreotide.
  • 3. Subjects with signed informed consent by themselves or their parents or legal guardians.
  • 4. Patient's Endocrinologist has determined that the patient cannot be safely managed with standard medical therapy (failed) and surgery is recommended to prevent future episodes of severe hypoglycemia and preserve brain function.
  • 1. Any other major illness or condition that in the investigator's judgment will substantially increase the risk associated with the subject's participation in this study.
  • 2. Patient must not have any contraindication to MRI as evaluated by a standardized MRI safety questionnaire. If MRI is contraindicated, and patient meets inclusion criteria and has no other contraindications study will be conducted in PET/CT scanner.
  • 3. Cases in which surgery will not be considered by parents or guardians.

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Washington University School of Medicine,

Ana Maria Arbelaez, MD, MSCI, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

2030-01-01