RECRUITING

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

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Conditions

OSASleep ApneaObstructive Sleep ApneaAlzheimer DiseasesleepSleep DisorderAlzheimer

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.

Official Title

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

Quick Facts

Study Start:2021-06-30
Study Completion:2025-03-20
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05094271

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Age 65-85 years
  2. 2. Gender: Men or Women
  3. 3. MOCA \> 26
  4. 4. Independently living and able to drive
  5. 5. OSA (AHI ≥ 15/h) or no OSA
  6. 6. Subjects must consent to waiving their right to obtain their PHS score (since the score is not yet actionable and could lead to social stress and ethical dilemmas)
  1. 1. Currently smoking
  2. 2. History of COPD or asthma
  3. 3. Heart Failure Class III or IV, unstable cardiovascular disease, or uncontrolled hypertension
  4. 4. Neuromuscular Disease
  5. 5. Drowsy Driving (ESS \> 18/24)
  6. 6. Inability to complete study procedures, such as questionnaire that are only available/validated in English
  7. 7. Lack of decisional capacity to provide informed consent
  8. 8. Participants in whom magnetic resonance imaging Magnetic Resonance Imaging \[MRI\] is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant
  9. 9. Presence of a brain tumor or lobar stroke
  10. 10. Current drug or alcohol abuse/dependence
  11. 11. Prisoners

Contacts and Locations

Study Contact

Pam DeYoung
CONTACT
8582462154
sleepresearch@health.ucsd.edu
Pamela DeYoung
CONTACT
8582462154
pdeyoung@health.ucsd.edu

Study Locations (Sites)

UCSD Sleep Research
La Jolla, California, 92037
United States

Collaborators and Investigators

Sponsor: University of California, San Diego

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-06-30
Study Completion Date2025-03-20

Study Record Updates

Study Start Date2021-06-30
Study Completion Date2025-03-20

Terms related to this study

Keywords Provided by Researchers

  • sleep
  • OSA
  • Sleep Apnea
  • Obstructive Sleep Apnea
  • Alzheimer Disease
  • Sleep Disorder
  • Alzheimer

Additional Relevant MeSH Terms

  • OSA
  • Sleep Apnea
  • Obstructive Sleep Apnea
  • Alzheimer Disease