Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

Description

Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.

Conditions

OSA, Sleep Apnea, Obstructive Sleep Apnea, Alzheimer Disease

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Study Overview

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Study Details

Study overview

Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to the progression of Alzheimer's disease.

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

Condition
OSA
Intervention / Treatment

-

Contacts and Locations

La Jolla

UCSD Sleep Research, La Jolla, California, United States, 92037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age 65-85 years
  • 2. Gender: Men or Women
  • 3. MOCA \> 26
  • 4. Independently living and able to drive
  • 5. OSA (AHI ≥ 15/h) or no OSA
  • 6. Subjects must consent to waiving their right to obtain their PHS score (since the score is not yet actionable and could lead to social stress and ethical dilemmas)
  • 1. Currently smoking
  • 2. History of COPD or asthma
  • 3. Heart Failure Class III or IV, unstable cardiovascular disease, or uncontrolled hypertension
  • 4. Neuromuscular Disease
  • 5. Drowsy Driving (ESS \> 18/24)
  • 6. Inability to complete study procedures, such as questionnaire that are only available/validated in English
  • 7. Lack of decisional capacity to provide informed consent
  • 8. Participants in whom magnetic resonance imaging Magnetic Resonance Imaging \[MRI\] is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant
  • 9. Presence of a brain tumor or lobar stroke
  • 10. Current drug or alcohol abuse/dependence
  • 11. Prisoners

Ages Eligible for Study

65 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Study Record Dates

2025-03-20