This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) as well as recurrent medulloblastoma (MB). PEP-CMV is a vaccine mixture of a peptide referred to as Component A. Component A is a synthetic long peptide (SLP) of 26 amino acid residues from human pp65. The SLPs encode multiple potential class I, class II, and antibody epitopes across several haplotypes. Component A will be administered as a stable water:oil emulsion in Montanide ISA 51. Funding Source - FDA OOPD
High Grade Glioma, Diffuse Intrinsic Pontine Glioma, Recurrent Medulloblastoma
This study will address the question of whether targeting CMV antigens with PEP-CMV can serve as a novel immunotherapeutic approach in pediatric patients with newly-diagnosed high-grade glioma (HGG) or diffuse intrinsic pontine glioma (DIPG) as well as recurrent medulloblastoma (MB). PEP-CMV is a vaccine mixture of a peptide referred to as Component A. Component A is a synthetic long peptide (SLP) of 26 amino acid residues from human pp65. The SLPs encode multiple potential class I, class II, and antibody epitopes across several haplotypes. Component A will be administered as a stable water:oil emulsion in Montanide ISA 51. Funding Source - FDA OOPD
PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
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Children's Hospital Colorado, Aurora, Colorado, United States, 80045
Children's National Medical Center, Washington, District of Columbia, United States, 20010
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States, 60611
Dana-Farber Cancer Institute, Boston, Massachusetts, United States, 02215
Duke University Medical Center, Durham, North Carolina, United States, 27710
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 45229
Nationwide Children's Hospital, Columbus, Ohio, United States, 43205
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 19104
Texas Children's Hospital, Houston, Texas, United States, 77030
Seattle Children's Hospital, Seattle, Washington, United States, 98105
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
3 Years to 25 Years
ALL
No
Nationwide Children's Hospital,
Eric Thompson, MD, STUDY_CHAIR, Duke University
Daniel Landi, MD, STUDY_CHAIR, Duke University
Maryam Fouladi, MD, STUDY_CHAIR, Nationwide Children's Hospital
2030-06-15