RECRUITING

Immunomodulatory Effects of Fasting in Healthy Adults

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Fasting

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a clinical trial assessing the effects of fasting on the immune system in healthy adults. Immune profiling, gene expression profiling, and flow cytometry on peripheral blood mononuclear cells (PBMCs) will be performed and we hypothesize that a period of fasting will alter the immune system in healthy adults.

Official Title

Immunomodulatory Effects of Fasting in Healthy Adults

Quick Facts

Study Start:2022-03-25
Study Completion:2024-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05104502

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:20 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age: 20-40 years, to constitute a young study population
  2. * Gender: male subjects, to control for gender differences
  3. * BMI: 19-27 kg/m2 to constitute a normal/healthy weight population
  4. * Weight: 120 lbs or more
  5. * Fasting glucose: 70-100 mg/dL, to ensure that fasting can be tolerated without inducing dangerously low levels of blood glucose
  6. * Subjects must be willing to undergo a period of 36 hours of water-only fasting
  7. * Subjects must be willing to collect samples of each bowel movement produced throughout the entire study period for microbiome analysis
  8. * Subjects must be willing to collect blood pricks for blood glucose levels using a Contour Next One Blood Glucose Testing Kit during the fasting stage of the study protocol.
  1. * Current smoking
  2. * Anemia
  3. * Pregnancy or current breastfeeding
  4. * Chronic diseases including diabetes mellitus, thyroid disease, metabolic syndrome, cancer, or previous cardiovascular events
  5. * Gastrointestinal diseases including irritable bowel syndrome, Crohn's disease, ulcerative colitis, celiac disease
  6. * Consumption of \>1 alcoholic drink/day
  7. * Extreme dietary or exercise patterns
  8. * Recent weight fluctuations (greater than 10% in the last six months)
  9. * Regular use of over-the-counter allergy or pain medications (\>1/week)
  10. * Taking prescription lipid medications (e.g. statins) or other supplements known to alter lipoprotein metabolism such as isoflavones
  11. * Use of hormonal birth control including oral contraception pills, hormonal IUDs or rings, or hormonal birth control patches

Contacts and Locations

Study Contact

Antonio Ji
CONTACT
916-551-2630
ajixu@ucdavis.edu

Study Locations (Sites)

UC Davis
Sacramento, California, 95816
United States

Collaborators and Investigators

Sponsor: University of California, Davis

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-03-25
Study Completion Date2024-12

Study Record Updates

Study Start Date2022-03-25
Study Completion Date2024-12

Terms related to this study

Additional Relevant MeSH Terms

  • Fasting