Preventing Cognitive Decline by Reducing BP Target Trial

Description

The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health \& Hospital System.

Conditions

Cognitive Decline, Blood Pressure, Hypertension

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Study Overview

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Study Details

Study overview

The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health \& Hospital System.

Preventing Cognitive Decline by Reducing BP Target Trial

Preventing Cognitive Decline by Reducing BP Target Trial

Condition
Cognitive Decline
Intervention / Treatment

-

Contacts and Locations

Dallas

UT Southwestern Medical Center, Dallas, Texas, United States, 75390

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * High BP defined as at least 1 BP readings of SBP \>= 130 or DBP \>=80 during the 24 months prior to enrollment
  • * Clinic visit with primary care provider within the last 24 months
  • * Ability to write and speak English or Spanish
  • * 70 years of age or older
  • * Ability to understand and willingness to provide informed consent
  • * Owns a smartphone
  • * Blood pressure consistently \<130/80 mmHg
  • * Presence of dementia, Alzheimer's disease, or significant neurological disease
  • * Major and unstable heart disease (e.g., acute heart failure (systolic or diastolic), acute on chronic heart failure (systolic or diastolic), acute coronary syndrome or cardiac arrest, liver or renal transplantation
  • * Under 70 years of age
  • * Inability to write or speak English or Spanish
  • * Chronic kidney disease stage 5 or ESKD
  • * Chemotherapy
  • * Any conditions judged by the medical providers to contraindicate participation due to risk to patient safety or lack of adherence
  • * Expected life expectancy under a year

Ages Eligible for Study

70 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Study Record Dates

2025-08-31