Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis

Description

Adverse outcomes in surgical sepsis patients are secondary to dysregulated emergency myelopoiesis, and expansion of myeloid-derived suppressor cells. Here we propose to determine the underlying mechanisms behind the increased expansion of these leukocyte populations and the underlying mechanisms that drive inflammation and immune suppression.

Conditions

Sepsis, Trauma Injury

Talk to us

Study Overview

On this page

Study Details

Study overview

Adverse outcomes in surgical sepsis patients are secondary to dysregulated emergency myelopoiesis, and expansion of myeloid-derived suppressor cells. Here we propose to determine the underlying mechanisms behind the increased expansion of these leukocyte populations and the underlying mechanisms that drive inflammation and immune suppression.

Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis Pathobiology Subtitle: Pathological Myeloid Activation After Sepsis and Trauma

Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis

Condition
Sepsis
Intervention / Treatment

-

Contacts and Locations

Gainesville

UF Health at Shands hospital, Gainesville, Florida, United States, 32610

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. age ≥18 years
  • 2. meets criteria for sepsis/septic shock by Sepsis-3 consensus criteria.
  • 1. have disease states that predispose to significant immune system dysfunction
  • 2. have comorbidity burden or goals of care that preclude recovery after sepsis. These criteria include:
  • 3. known pregnancy
  • 4. enrollment \>96 hours after suspected sepsis onset
  • 5. pre-hospitalization bedridden performance status (WHO/Zubrod score ≥4)
  • 6. subsequent clinical adjudication diagnosis not consistent with sepsis/septic shock by Sepsis-3 criteria.
  • 7. Burn injury greater than 20% total body surface area (tBSA)
  • 1. All adults age ≥ 18 years
  • 2. Blunt trauma patient with a. Injury Severity Score (ISS) greater than or equal to 25 b. ISS \> 15 and one of the following: i. \> 4 units of PRBC or \>3 units of whole blood or \>1500 ml of autogenous blood product in the first 24 hours of admission ii. AIS (acute injury score) \> 2 spine iii. Shock on arrival (Systolic blood pressure (SBP) \< 90)
  • 1. Patients not expected to survive greater than 48 hours.
  • 2. Prisoners.
  • 3. Pregnancy.
  • 4. Previous bone marrow transplantation.
  • 5. Patients with End Stage Renal Disease.
  • 6. Patients with any pre-existing hematological disease.
  • 7. Patients deemed to be futile care or have advanced directives limiting resuscitative efforts.
  • 8. Known HIV infection with CD4+ count \<200 cells/mm3
  • 9. Burn injury greater than 20% tBSA

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Florida,

Lyle Moldawer, PhD, PRINCIPAL_INVESTIGATOR, University of Florida

Philip Efron, MD, PRINCIPAL_INVESTIGATOR, University of Florida

Tyler Loftus, MD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2026-04