RECRUITING

Testing the Contribution of Orbitofrontal Cortex Networks to Decision-making

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This research study examines the contribution of orbitofrontal cortex (OFC) networks to decision-making.

Official Title

Testing the Contribution of Orbitofrontal Cortex Networks to Decision-making

Quick Facts

Study Start:2022-07-12

Study Completion:2026-08-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05111223

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Age between 18 and 40 years old * Right-handed * Fluent English speakers	* History of significant neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.) * History of major psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, substance use disorder, etc.) * Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.) * Significant cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.) * Current use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.) * Smell or taste dysfunction * History of significant allergies requiring hospitalization for treatment * History of severe asthma requiring hospitalization for treatment * Habitual smoking * History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.) * Dieting or fasting * Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.) * Electronic devices (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.) * History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers * Claustrophobia * Pregnancy * Predisposition to seizures (e.g., personal history of seizures, family history of seizures epilepsy, pregnancy, alcoholism, etc.) * Use of medications that increase the likelihood of seizures (e.g., bupropion SR, citalopram, duloxetine, ketamine, gamma-hydroxybutyrate, etc.) * History of surgical procedures performed on the brain or spinal cord * History of severe head trauma followed by loss of consciousness * History of fainting spells or syncope * Hearing problems or tinnitus

Inclusion Criteria

Exclusion Criteria

* Age between 18 and 40 years old
* Right-handed
* Fluent English speakers

* History of significant neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.)
* History of major psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, substance use disorder, etc.)
* Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.)
* Significant cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.)
* Current use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.)
* Smell or taste dysfunction
* History of significant allergies requiring hospitalization for treatment
* History of severe asthma requiring hospitalization for treatment
* Habitual smoking
* History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.)
* Dieting or fasting
* Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.)
* Electronic devices (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.)
* History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers
* Claustrophobia
* Pregnancy
* Predisposition to seizures (e.g., personal history of seizures, family history of seizures epilepsy, pregnancy, alcoholism, etc.)
* Use of medications that increase the likelihood of seizures (e.g., bupropion SR, citalopram, duloxetine, ketamine, gamma-hydroxybutyrate, etc.)
* History of surgical procedures performed on the brain or spinal cord
* History of severe head trauma followed by loss of consciousness
* History of fainting spells or syncope
* Hearing problems or tinnitus

Contacts and Locations

Study Contact

Christina Zelano, PhD

CONTACT

312-503-4437

c-zelano@northwestern.edu

Greg Lane, PhD

CONTACT

312-503-7244

Principal Investigator

Christina Zelano, PhD

PRINCIPAL_INVESTIGATOR

Assistant Professor

Study Locations (Sites)

Northwestern University

Chicago, Illinois, 60657

United States

Collaborators and Investigators

Sponsor: Northwestern University

Christina Zelano, PhD, PRINCIPAL_INVESTIGATOR, Assistant Professor

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-12

Study Completion Date2026-08-31

Study Record Updates

Study Start Date2022-07-12

Study Completion Date2026-08-31

Terms related to this study

Additional Relevant MeSH Terms

Healthy