Parathyroid Allotransplantation in Medically Refractory Hypoparathyroidism

Eligibility Criteria

• * Individual diagnosed with hypocalcemia secondary to
• 1. Hypoparathyroidism:
• 1. Prior anterior cervical neck surgery resulting in hypoparathyroidism
• 2. Congenital absence or malformation of parathyroid glands during development
• 2. Presence of hypoparathyroidism for at least one year
• 3. Failure of medical treatment for hypocalcemia, including need for IV calcium, with negative impact on quality of life and daily function
• 4. Age 18-80 years
• 5. Lives in the greater Birmingham region for the duration of the trial
• 6. Fluent in the English Language
• 7. Willing to comply with screening, protocol and all required procedures
• 1. Any active malignancy, except non-melanoma skin cancer
• 2. Dependence on nursing home or other long-term care provider
• 3. History of ischemic cardiomyopathy with ejection fraction \<20%, uncontrolled diabetes mellitus (Hgb A1c \>10), thrombophilia or other clotting or bleeding disorders, significant heart, liver, kidney or central nervous system disease
• 4. History of significant psychiatric illness
• 5. Severe osteoporosis
• 6. Allergy, hypersensitivity, or intolerance of expected immunosuppressive agents (i.e. Thymoglobulin®, tacrolimus, etc.)
• 7. Documented history of gross non-adherence to medical therapies
• 8. Significant functional/cognitive impairment without reliable caregiver
• 9. Presence of active documented systemic infection or recent systemic infection within the past 3 months
• 10. Seropositivity for HIV, HBV core antibody or antigen, HCV, HTLV-1
• 11. Current smoker (smoking cessation must have occurred 3 months prior to enrollment)
• 12. Chemical and/or alcohol dependency or abuse
• 13. Psychosocial problems (including alcoholism, drug abuse, documented behavioral disorders)
• 14. Resources deemed inadequate to support necessary post-transplant care