Wearable Sensors and Molecular Omics to Detect and Mitigate Cell Therapy Adverse Events

Description

The purpose of this study is to monitor physiological and molecular changes during and following CAR-T cancer cell therapy, towards improved management of adverse events including Cytokine Release Syndrome and neurotoxicity. Our study aims are to improved early detection and precise management of adverse events for patients receiving Chimeric antigen receptor T- cell (CAR-T): 1. To assess the feasibility, including accuracy, usability, and usefulness of wearable sensors in CAR-T patients. 2. To generate comprehensive multiomic profile analysis following CAR-T therapy. 3. To perform integrated analysis of wearables sensor data, omics data, and symptom/clinical data.

Conditions

Hodgkin Lymphoma, Non Hodgkin Lymphoma, Leukemia, Multiple Myeloma

Study Overview

Study Details

Study overview

The purpose of this study is to monitor physiological and molecular changes during and following CAR-T cancer cell therapy, towards improved management of adverse events including Cytokine Release Syndrome and neurotoxicity. Our study aims are to improved early detection and precise management of adverse events for patients receiving Chimeric antigen receptor T- cell (CAR-T): 1. To assess the feasibility, including accuracy, usability, and usefulness of wearable sensors in CAR-T patients. 2. To generate comprehensive multiomic profile analysis following CAR-T therapy. 3. To perform integrated analysis of wearables sensor data, omics data, and symptom/clinical data.

Wearable Sensors and Molecular Omics to Detect and Mitigate Cell Therapy Adverse Events

Wearable Sensors and Molecular Omics to Detect and Mitigate Cell Therapy Adverse Events

Condition
Hodgkin Lymphoma
Intervention / Treatment

-

Contacts and Locations

Palo Alto

Stanford University, Palo Alto, California, United States, 94305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participant must be in the process of undergoing cancer cell therapy at Stanford University.
  • * Adults \> 18 years
  • * Any cell target may be used. (e.g. CD19, CD22, Bispecific CD19/22, Bispecific CD19/20, etc.)
  • * English speaking
  • * Assessed ability for caregiver/patient to use wearable devices and independently perform blood microsample collection
  • * In the investigator's judgment, the subject is unlikely to comply with all protocolrequired study visits or procedures.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Surbhi Sidana, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2025-09