Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity

Description

In this study, doctors want to find out more about why people who lose weight often regain the weight that they have lost once they resume a regular diet and whether hormones might play a role in weight regain. The study is divided into two parts, called the meal replacement period and the follow-up period. The meal replacement period will consist of drinking a shake for breakfast and lunch and eating a frozen meal for dinner that is calorie controlled. Individuals will also be asked to eat two servings of fruit and three servings of vegetables each day. The study will provide the shakes and the frozen entrees, participants are asked to supply the fruits and vegetables. Participation in this study will last for up to 35 weeks. There will be 10 in-person visits and 13 visits by phone or over Zoom over the 35 weeks.

Conditions

Childhood Obesity

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Study Overview

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Study Details

Study overview

In this study, doctors want to find out more about why people who lose weight often regain the weight that they have lost once they resume a regular diet and whether hormones might play a role in weight regain. The study is divided into two parts, called the meal replacement period and the follow-up period. The meal replacement period will consist of drinking a shake for breakfast and lunch and eating a frozen meal for dinner that is calorie controlled. Individuals will also be asked to eat two servings of fruit and three servings of vegetables each day. The study will provide the shakes and the frozen entrees, participants are asked to supply the fruits and vegetables. Participation in this study will last for up to 35 weeks. There will be 10 in-person visits and 13 visits by phone or over Zoom over the 35 weeks.

Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity

Adaptive Mechanisms Responsible for Weight Change in Youth With Obesity

Condition
Childhood Obesity
Intervention / Treatment

-

Contacts and Locations

Chicago

Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, United States, 60611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 11 to less than 16 years old
  • * BMI \> 30 kg/m\^2 or 95th BMI percentile
  • * Tanner stage 2, 3, or 4
  • * Tanner stage 1 and 5
  • * Prior bariatric surgery
  • * Current or recent (\< 3 months prior to enrollment) use of anti-obesity medication(s) defined as orlistat, metformin, phentermine, topiramate, combination phentermine/topiramate, liraglutide, and/or combination naltrexone/bupropion (monotherapy use of naltrexone or bupropion is not an exclusion)
  • * Monogenic and hypothalamic obesity
  • * Polycystic ovary syndrome (diagnosed by a physician)
  • * Pregnancy or planned pregnancy
  • * Current use of supplemental hormones
  • * Individuals with a diagnosed eating disorder of anorexia nervosa, bulimia or binge eating disorder
  • * Type 1 or 2 diabetes
  • * Treatment with growth hormones
  • * Thyroid disease/problem
  • * Has had cancer in the last 10 years

Ages Eligible for Study

11 Years to 15 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Ann & Robert H Lurie Children's Hospital of Chicago,

Justin Ryder, PhD, PRINCIPAL_INVESTIGATOR, Ann & Robert H Lurie Children's Hospital of Chicago

Study Record Dates

2028-01-01