Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

Description

The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.

Conditions

Depression, HIV-1-infection, Inflammation

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Study Overview

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Study Details

Study overview

The purpose of this randomized controlled trial is to understand how a cognitive-behavioral treatment (a form of psychological treatment) for depression changes the gut microbiome (micro-organisms that regulate the health of the gut), immune system, and the brain functioning in people living with HIV.

Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)

Condition
Depression
Intervention / Treatment

-

Contacts and Locations

Miami

University of Miami, Miami, Florida, United States, 33136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age 18 or older
  • 2. Speaks and reads English
  • 3. Verified HIV+ status with antiretroviral medications bearing his/her name
  • 4. Current diagnosis on Major Depressive Disorder (MDD) using a structured clinical interview (DIAMOND) or Hamilton Rating Scale for Depression scores of 17 or greater
  • 5. If prescribed antidepressants, on a stable regimen and dose for at least 2 months
  • 6. Suppressed HIV viral load (\< 200 copies/mL)
  • 7. Able to complete Functional Magnetic Resonance Imaging (fMRI) scans (i.e., no claustrophobia, no metal implants, no pacemaker, and BMI \< 40)
  • 1. Unable to provide informed consent
  • 2. Active, untreated major mental illness
  • 3. Pregnancy at baseline
  • 4. Received CBT for depression in the past 2 years
  • 5. Otherwise eligible but does not complete baseline biospecimen collection and fMRI visit

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Florida International University,

Adam W Carrico, PhD, PRINCIPAL_INVESTIGATOR, University of Miami

Study Record Dates

2026-07-31