Risk and Benefits of Electronic Cigarettes to Older Smokers At High Risk for Lung Cancer

Eligibility Criteria

• * Aged 50-80 years who currently smokes at least 1 or more combustible cigarettes per day OR who is a nondaily smoker (any self-reported smoking in the past 30 days) with a 20 pack-year history.
• * Being interested in trying ECs to change CC smoking behavior
• * Willing to have biospecimen samples taken, either in-home using a mobile phlebotomoty service, or at an approved collection site
• * Have an address where he/she can receive mail
• * Being fluent in spoken and written English
• * Agrees to comply with all MD Anderson institutional policies related to COVID-19 screening prior to any in-person research visit.
• * The individual agrees to not engage in study procedures or interactions with study personnel while operating a vehicle.
• * Individuals who report depressive symptoms in the moderately severe or severe range on the PHQ-9 (scores of 15 or above); or who report current suicidal ideation on the PHQ-9
• * Have ever had a diagnosis of lung cancer, have uncontrolled or unstable medical condition (e.g., uncontrolled hypertension, angina, diabetes)
• * Unwilling to consent for blood draw
• * Evidence of cognitive deficits or instability that would preclude reliable study participation
• * Being pregnant, engaging in breast-feeding, or being of childbearing potential and engaging in sexual activity that could lead to pregnancy and is not protected by a medically acceptable, effective method of birth control while enrolled in the study, as determined by self-report. Medically acceptable contraceptives include: (1) approved hormonal contraceptives (such as birth control pills, patches, implants or injections), (2) barrier methods (such as a condom or diaphragm) used with a spermicide, or (3) an intrauterine device (IUD). Contraceptive measures sold for emergency use after unprotected sex are not acceptable methods for routine use.
• * Considered by the investigator to be an unsuitable or unstable candidate (including but not limited to the following situations: unwilling or unable to comply with study procedures)
• * Individuals who reside in an area that is outside of our shipping company or mobile phlebotomty contractors' areas of operation or in a jurisdiction outside of our medical staff's licensure (if unable to attend in-person clinic visits) AND who decline to come in to clinic to provide necessary samples and/or collect study products.