Vitrectomy to remove an epiretinal membrane (ERM) is one of the most common procedures performed by retinal surgeons. Patients who present with significant macular changes on optical coherence tomography (OCT) but relatively good vision are often advised to defer surgery until vision declines to 20/40 or worse. However, it is unknown if delaying surgery, which allows the foveal architecture to remain compromised and potentially to deteriorate, results in worse visual acuity outcomes than if surgery is performed earlier. In addition, there is a need to better understand predictors of outcomes when surgery is performed and predictors of progression when surgery is deferred. Finally, one of the most common presenting symptoms from an ERM is distortion or metamorphopsia. There are several objective measures of metamorphopsia but none have ever been employed to evaluate ERMs in a randomized clinical trial (RCT) and their usefulness is unknown. The purposes of this study are to better understand the optimal timing of surgery to produce the best visual result, to better understand predictors of outcomes in those who undergo surgery and predictors of progression in those whose are observed, and to better characterize and evaluate the usefulness of metamorphopsia and reading speed measures.
Epiretinal Membrane
Vitrectomy to remove an epiretinal membrane (ERM) is one of the most common procedures performed by retinal surgeons. Patients who present with significant macular changes on optical coherence tomography (OCT) but relatively good vision are often advised to defer surgery until vision declines to 20/40 or worse. However, it is unknown if delaying surgery, which allows the foveal architecture to remain compromised and potentially to deteriorate, results in worse visual acuity outcomes than if surgery is performed earlier. In addition, there is a need to better understand predictors of outcomes when surgery is performed and predictors of progression when surgery is deferred. Finally, one of the most common presenting symptoms from an ERM is distortion or metamorphopsia. There are several objective measures of metamorphopsia but none have ever been employed to evaluate ERMs in a randomized clinical trial (RCT) and their usefulness is unknown. The purposes of this study are to better understand the optimal timing of surgery to produce the best visual result, to better understand predictors of outcomes in those who undergo surgery and predictors of progression in those whose are observed, and to better characterize and evaluate the usefulness of metamorphopsia and reading speed measures.
Randomized Trial Comparing Immediate Vs. Deferred Surgery for Symptomatic ERM
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Mayo Clinic Arizona, Scottsdale, Arizona, United States, 85259
Kent W. Small, MD, AMC, Glendale, California, United States, 91203-1971
Salehi Retina Institute Inc., Huntington Beach, California, United States, 92647-8693
Loma Linda University, Loma Linda, California, United States, 92354
Retina Vitreous Associates, Northern California Retina Vitreous Assoc Medical Group, Inc., Mountain View, California, United States, 94040-4123
East Bay Retina Consultants, Inc., Oakland, California, United States, 94609-3028
Regents of the University of California, Davis, DBA University of California, Davis, Sacramento, California, United States, 95817
Macula Retina Vitreous Institute, Torrance, California, United States, 90503
Florida Retina Institute, James A. Staman, MD, PA- Jacksonville, Jacksonville, Florida, United States, 32216
Sarasota Retina Institute, Sarasota, Florida, United States, 34239
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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50 Years to
ALL
No
Jaeb Center for Health Research,
2026-12-31