Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

Description

Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.

Conditions

Physical Inactivity, Phosphate Overload, Visceral Obesity

Study Overview

Study Details

Study overview

Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.

Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

Condition
Physical Inactivity
Intervention / Treatment

-

Contacts and Locations

Dallas

University of Texas Southwestern, Dallas, Texas, United States, 75209

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. history of cardiopulmonary disease or chronic kidney disease,
  • 2. treatment with antihypertensive medications,
  • 3. estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2, (4) diabetes mellitus or other systemic illness,

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Wanpen Vongpatanasin, MD, PRINCIPAL_INVESTIGATOR, Wanpen.Vongpatanasin@UTSouthwestern.edu

Study Record Dates

2028-03-30