RECRUITING

Music Therapy for Patients With Alzheimer's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD). 60 patients with MCI or mild dementia due to AD will receive two 30 minutes reminiscence-targeted virtual music therapy interventions per week for 8 weeks (a total of 16 sessions). Participants' (or supported by the study partner) self-reported and measurable outcomes including cognitive, anxiety, quality of life, and autobiographical memory will be assessed before and after the 8-week course of treatment. Blood-oxygenation level-dependent (BOLD) in functional magnetic resonance imaging (fMRI) will also be also measured before and after the 8-week course of treatment.

Official Title

Music Therapy for Autobiographical Memory and Neuropsychiatric Symptoms in Alzheimer Disease

Quick Facts

Study Start:2022-07-18
Study Completion:2026-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05151562

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 89 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-89
  2. * Mild Cognitive Impairment (MoCA score: 18-25) or Early AD (MoCA score: 17-24)
  1. * Head trauma, traumatic brain injury, or concussion with loss of consciousness for \>2 minutes
  2. * Claustrophobia incompatible with MRI scanning
  3. * Medical device incompatible with MRI scanning (e.g. cardiac pacemaker, implanted cardiac defibrillator, aneurysm brain clip, inner ear implant)
  4. * Prior history as a metal worker and/or certain metallic objects in the body
  5. * Exclusion Criteria will be carefully determined by the MRI screening form.

Contacts and Locations

Study Contact

Alexander Pantelyat, MD
CONTACT
4105023290
apantel1@jhmi.edu
Kyurim Kang, PhD
CONTACT
4437422223
kkang19@jhmi.edu

Principal Investigator

Alexander Pantelyat, MD
PRINCIPAL_INVESTIGATOR
Department of Neurology, Johns Hopkins School of Medicine

Study Locations (Sites)

Johns Hopkins School of Medicine
Baltimore, Maryland, 21205
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Alexander Pantelyat, MD, PRINCIPAL_INVESTIGATOR, Department of Neurology, Johns Hopkins School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-07-18
Study Completion Date2026-04

Study Record Updates

Study Start Date2022-07-18
Study Completion Date2026-04

Terms related to this study

Keywords Provided by Researchers

  • Mild Cognitive Impairment (MCI)
  • Alzheimer's Disease (AD)
  • functional magnetic resonance imaging (fMRI)
  • Autobiographical memory
  • Virtual Music Therapy
  • Music Therapy

Additional Relevant MeSH Terms

  • Mild Cognitive Impairment
  • Alzheimer Disease