Music Therapy for Patients With Alzheimer's Disease

Description

This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD). 60 patients with MCI or mild dementia due to AD will receive two 30 minutes reminiscence-targeted virtual music therapy interventions per week for 8 weeks (a total of 16 sessions). Participants' (or supported by the study partner) self-reported and measurable outcomes including cognitive, anxiety, quality of life, and autobiographical memory will be assessed before and after the 8-week course of treatment. Blood-oxygenation level-dependent (BOLD) in functional magnetic resonance imaging (fMRI) will also be also measured before and after the 8-week course of treatment.

Conditions

Mild Cognitive Impairment, Alzheimer Disease

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Study Overview

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Study Details

Study overview

This study is designed to assess the feasibility that individualized reminiscence-based virtual music therapy sessions can enhance autobiographical memory, mood, and cognition in patients with mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD). 60 patients with MCI or mild dementia due to AD will receive two 30 minutes reminiscence-targeted virtual music therapy interventions per week for 8 weeks (a total of 16 sessions). Participants' (or supported by the study partner) self-reported and measurable outcomes including cognitive, anxiety, quality of life, and autobiographical memory will be assessed before and after the 8-week course of treatment. Blood-oxygenation level-dependent (BOLD) in functional magnetic resonance imaging (fMRI) will also be also measured before and after the 8-week course of treatment.

Music Therapy for Autobiographical Memory and Neuropsychiatric Symptoms in Alzheimer Disease

Music Therapy for Patients With Alzheimer's Disease

Condition
Mild Cognitive Impairment
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 21205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-89
  • * Mild Cognitive Impairment (MoCA score: 18-25) or Early AD (MoCA score: 17-24)
  • * Head trauma, traumatic brain injury, or concussion with loss of consciousness for \>2 minutes
  • * Claustrophobia incompatible with MRI scanning
  • * Medical device incompatible with MRI scanning (e.g. cardiac pacemaker, implanted cardiac defibrillator, aneurysm brain clip, inner ear implant)
  • * Prior history as a metal worker and/or certain metallic objects in the body
  • * Exclusion Criteria will be carefully determined by the MRI screening form.

Ages Eligible for Study

18 Years to 89 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins University,

Alexander Pantelyat, MD, PRINCIPAL_INVESTIGATOR, Department of Neurology, Johns Hopkins School of Medicine

Study Record Dates

2026-04