A Pilot Study to Increase Utilization of GDMT in Patients With HFrEF

Description

The purpose of this study is to test a clinical decision support (CDS) tool that provides clinicians (cardiologists and nurse practitioners) medication recommendations regarding guideline directed medical therapy (GDMT) in patients with heart failure and reduced ejection fraction (HFrEF).

Conditions

Heart Failure

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of this study is to test a clinical decision support (CDS) tool that provides clinicians (cardiologists and nurse practitioners) medication recommendations regarding guideline directed medical therapy (GDMT) in patients with heart failure and reduced ejection fraction (HFrEF).

A Pilot Study to Increase Utilization of Guideline Directed Medical Therapy in Patients With HFrEF

A Pilot Study to Increase Utilization of GDMT in Patients With HFrEF

Condition
Heart Failure
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Cedars Sinai Medical Center, Los Angeles, California, United States, 90048

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of HFrEF (left ejection fraction \< 40%, assessed by transthoracic echo, cardiac MRI, cardiac SPECT) within the past year.
  • * New York Heart Association (NYHA) class II-III at most recent screening assessment.
  • * GDMT composite score of less than or equal to 50% at baseline
  • * Previous contraindication to beta blockers, ACE inhibitors, and/or ARB.
  • * Baseline creatinine \> 2 mg/dl or potassium level at baseline \> 5 mEq/L or eGFR \<30 mL/min/1.73 m2.
  • * Baseline systolic blood pressure \< 100 mmHg.
  • * Concomitant use of ACE, ARB, and/or ARNI
  • * Polycystic kidney disease
  • * History of angioedema
  • * History of or currently on a transplant list
  • * Left ventricular assist device
  • * Uncontrolled asthma
  • * Severe COPD
  • * Cirrhosis
  • * Currently receiving hospice or comfort care
  • * Patient not proficient with written and spoken English
  • * Patient has diminished decision making capability
  • * History of non-compliance

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Cedars-Sinai Medical Center,

Raj Khandwalla, MD, PRINCIPAL_INVESTIGATOR, Cedars-Sinai Medical Center

Study Record Dates

2023-09-25