Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

Description

This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide marked reduction in mTBI related headaches and symptoms in comparison to their placebo counterparts.

Conditions

TBI (Traumatic Brain Injury), Headache, Depression

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Study Overview

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Study Details

Study overview

This study will assess the combined effectiveness of repetitive transcranial magnetic stimulation (rTMS) and telehealth based therapy in helping manage mild traumatic brain injury (mTBI) related headaches. The investigators hypothesize that active rTMS combined with telehealth therapy will provide marked reduction in mTBI related headaches and symptoms in comparison to their placebo counterparts.

Combined Nonpharmacological Therapies for MTBI-Related Headaches

Combined Transcranial Magnetic Stimulation and Therapy for MTBI Related Headaches

Condition
TBI (Traumatic Brain Injury)
Intervention / Treatment

-

Contacts and Locations

San Diego

VA San Diego Healthcare System, San Diego, California, United States, 92161

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Mild Traumatic Brain Injury (mTBI)
  • 2. Chronic headaches \> 3 months after injury
  • 3. Aged 18-65
  • 4. No prior TMS treatment
  • 5. Persistent Headaches with an intensity \> 30 / 100
  • 6. No history of daily headache prior to mTBI
  • 1. Pregnant
  • 2. Pacemaker or any metal in body that would prevent MRI
  • 3. History of dementia or major psychiatric disease, such as bipolar disorder or schizophrenia
  • 4. Presence of any other chronic neuropathic pain states
  • 5. History of seizure
  • 6. Pending litigation
  • 7. Can't understand English
  • 8. History of chronic headache like migraine prior to mTBI
  • 9. Evidence in chart of exacerbation of depressive/anxiety symptoms, active substance dependence, suicidal intent or attempt within previous month

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Veterans Medical Research Foundation,

Albert Y Leung, MD, PRINCIPAL_INVESTIGATOR, San Diego Veterans Healthcare System

Study Record Dates

2025-08-31