IV Pulsed-Nicotine As a Model of Smoking: the Effects of Dose and Delivery Rate

Description

This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal. Will use pulsed IV nicotine administration which closely matches nicotine delivery by inhaled tobacco use.

Conditions

Nicotine Dependence

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Study Overview

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Study Details

Study overview

This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal. Will use pulsed IV nicotine administration which closely matches nicotine delivery by inhaled tobacco use.

IV Pulsed-Nicotine As a Model of Smoking: the Effects of Dose and Delivery Rate

IV Pulsed-Nicotine As a Model of Smoking: the Effects of Dose and Delivery Rate

Condition
Nicotine Dependence
Intervention / Treatment

-

Contacts and Locations

West Haven

VA Healthcare System, West Haven, Connecticut, United States, 06516

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female and male, aged 21 to 55 years;
  • * past year daily cigarette use, verified by urine cotinine levels above 100 ng/ml -lifetime history of e-cigarette use; in good health as verified by medical history -screening examination, and screening laboratory tests
  • * women, -using acceptable birth control methods.
  • * History of major medical or psychiatric disorders that the physician investigator deems as contraindicated for the participant to be in the study
  • * risk factors for EVALI (E-cigarette or Vaping Product Use-Associated Lung Injury) including history of lung diseases (e.g., asthma or COPD), vaping THC or CBD
  • * regular use of psychotropic medication (antidepressants, antipsychotics, or anxiolytics)
  • * current alcohol or substance use disorder for any other recreational or prescription drugs other than nicotine
  • * for women, pregnant as determined by pregnancy screening, or breast feeding
  • * seeking (or undergoing) treatment for tobacco dependence or smoking; reported aversion to e-cigarettes, or tobacco flavored e-liquid.

Ages Eligible for Study

21 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Yale University,

Mehmet Sofuoglu, M.D.,Ph.D, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2025-09-01