Lipoprotein Kinetics in T1D

Description

The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.

Conditions

Type 1 Diabetes

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Study Overview

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Study Details

Study overview

The purpose of this research study is to understand how type 1 diabetes (T1D) increases the risk for cardiovascular diseases (heart attack and stroke). To this end, the investigators will compare apolipoprotein and triglyceride kinetics in people wtih T1D and healthy control participants.

Apolipoprotein C3-loading of Apolipoprotein B100 Lipoproteins and Cardiovascular Disease in Patients with Type 1 Diabetes

Lipoprotein Kinetics in T1D

Condition
Type 1 Diabetes
Intervention / Treatment

-

Contacts and Locations

Columbia

University of Missouri School of Medicine, Columbia, Missouri, United States, 65212

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age: ≥18 but ≤45 years
  • * premenopausal/eumenorrheic and not pregnant or breastfeeding
  • * non-obese (body mass index ≥18.5\<30.0 kg/m2)
  • * Fasting plasma triglyceride \<150 mg/dL
  • * Fasting plasma glucose \<100 mg/dL
  • * Plasma glucose 2 h after a 75 g oral glucose challenge \<140 mg/dL
  • * HbA1c \<5.6%.
  • * stable insulin regimen (multiple daily insulin injections or continuous subcutaneous insulin) for at least 8 weeks before screening
  • * no use of diabetes medications other than insulin
  • * HbA1c \<6.5%, basal (overnight fasted)
  • * no severe symptomatic hypoglycemic event associated with a seizure or requiring help from other people or a medical facility in the 6 months prior to screening or metabolic testing
  • * more than 1.5 h of structured exercise/week
  • * use of tobacco products, excessive amounts of alcohol, or dietary supplements and/or medications known to affect lipid metabolism
  • * hypothyroidism or other disorders known to affect lipid metabolism
  • * conditions that would make it impossible to complete the study protocol

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Missouri-Columbia,

Bettina Mittendorfer, PRINCIPAL_INVESTIGATOR, University of Missouri-Columbia

Study Record Dates

2027-12-31