RECRUITING

Imaging Brain Fluids During Breathing

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Conditions

HealthyGlymphaticsCerebrospinal fluid

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.

Official Title

Neuroimaging the Impact of Respiration and Respiratory-gated Neuromodulation on Human Glymphatic Physiology

Quick Facts

Study Start:2022-01-18
Study Completion:2026-05-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05180981

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult age 18-70 years
  1. * No ferrous metal implanted in head or body
  2. * No history of major head trauma
  3. * No neurological or psychiatric disorder
  4. * Not using medication that affects brain function
  5. * No implanted electronic devices (e.g. pacemaker)
  6. * No implant that poses an MR contraindication
  7. * Not pregnant, suspect they are pregnant, or seeking to become pregnant
  8. * Not claustrophobic
  9. * No piercings or jewelry that cannot be removed
  10. * Does not weigh more than 250 pounds
  11. * Normal or contact-corrected normal vision
  12. * Conditions of skin or anatomy that affect left auricle or forehead skin and could impact placement of electrodes for tVNS or forehead stimulation
  13. * Diagnosis of significant cardiovascular or cerebrovascular disease \[e.g. congestive heart failure, stroke, cardiac conduction disorders (including: bundle branch block, heart block, long Q-T syndrome), history of asystole or non-sustained ventricular tachycardia.
  14. * Bradycardia (defined as resting heart rate \<50 bpm)
  15. * Hypotension defined as blood pressure \<90/60 mmHg

Contacts and Locations

Study Contact

Jessica Yee, BS
CONTACT
7742852038
jessyee@bu.edu
Courtney Zambello, BA
CONTACT
7812019815
cgz@bu.edu

Principal Investigator

Laura Lewis, PhD
PRINCIPAL_INVESTIGATOR
Boston University

Study Locations (Sites)

Massachusetts General Hospital
Boston, Massachusetts, 02114
United States
Boston University - Charles River Campus
Boston, Massachusetts, 02215
United States

Collaborators and Investigators

Sponsor: Boston University Charles River Campus

  • Laura Lewis, PhD, PRINCIPAL_INVESTIGATOR, Boston University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-01-18
Study Completion Date2026-05-01

Study Record Updates

Study Start Date2022-01-18
Study Completion Date2026-05-01

Terms related to this study

Keywords Provided by Researchers

  • Glymphatics
  • Cerebrospinal fluid

Additional Relevant MeSH Terms

  • Healthy