Imaging Brain Fluids During Breathing

Description

This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.

Conditions

Healthy

Talk to us

Study Overview

On this page

Study Details

Study overview

This study will perform magnetic resonance imaging (MRI) measurements of hemodynamics and cerebrospinal fluid flow across breathing tasks and during breath-locked neuromodulation.

Neuroimaging the Impact of Respiration and Respiratory-gated Neuromodulation on Human Glymphatic Physiology

Imaging Brain Fluids During Breathing

Condition
Healthy
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Boston

Boston University - Charles River Campus, Boston, Massachusetts, United States, 02215

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult age 18-70 years
  • * No ferrous metal implanted in head or body
  • * No history of major head trauma
  • * No neurological or psychiatric disorder
  • * Not using medication that affects brain function
  • * No implanted electronic devices (e.g. pacemaker)
  • * No implant that poses an MR contraindication
  • * Not pregnant, suspect they are pregnant, or seeking to become pregnant
  • * Not claustrophobic
  • * No piercings or jewelry that cannot be removed
  • * Does not weigh more than 250 pounds
  • * Normal or contact-corrected normal vision
  • * Conditions of skin or anatomy that affect left auricle or forehead skin and could impact placement of electrodes for tVNS or forehead stimulation
  • * Diagnosis of significant cardiovascular or cerebrovascular disease \[e.g. congestive heart failure, stroke, cardiac conduction disorders (including: bundle branch block, heart block, long Q-T syndrome), history of asystole or non-sustained ventricular tachycardia.
  • * Bradycardia (defined as resting heart rate \<50 bpm)
  • * Hypotension defined as blood pressure \<90/60 mmHg

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Boston University Charles River Campus,

Laura Lewis, PhD, PRINCIPAL_INVESTIGATOR, Boston University

Study Record Dates

2026-05-01