Sleep and Circadian Mechanisms in Hypertension

Description

This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).

Conditions

Hypertension, Cardiovascular Diseases, Cardiovascular Risk Factors, Circadian Rhythms, Sleep

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Study Overview

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Study Details

Study overview

This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).

Sleep and Circadian Mechanisms in Hypertension

Sleep and Circadian Mechanisms in Hypertension

Condition
Hypertension
Intervention / Treatment

-

Contacts and Locations

Portland

Oregon Health and Science University, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 25-64
  • * BMI 18.5-42kg/m2
  • * Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg)
  • * Over 5 pack-years of smoking;
  • * Prior shift work within 12 months prior to the study;
  • * Travel greater than three time zones for at least 3 months;
  • * History of heart failure, cardiomyopathy, or history of bypass surgery, angioplasty, or previous myocardial infarction;
  • * Acute or chronic diseases (except hypertension) that may affect outcome measures;
  • * History of psychological conditions;
  • * Sleep disorders, like severe sleep apnea, insomnia, etc.;
  • * Prescription medications (Contraceptives and anti-hypertensive medications are permissible);
  • * History of Illicit drug use and alcohol dependency;
  • * 30 days free of cannabis use prior to the study;
  • * Pregnancy;
  • * Upper cut-off of 160/100 mmHg for BP

Ages Eligible for Study

25 Years to 64 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Oregon Health and Science University,

Saurabh S Thosar, PhD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

2028-03-30