RECRUITING

Cardiopulmonary Bypass Induced Red Blood Cell Lysis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB. These results will be compared to existing laboratory-based methods for determining red blood cell damage to predict CPB assist device safety. Further, results from the studies described in this proposal will help develop therapeutic strategies to benefit patients by early detection of pfH and clearance protein levels that occur during CPB.

Official Title

Extra-Cellular Hemoglobin, Organ Injury in Extended Cardiopulmonary Bypass

Quick Facts

Study Start:2022-03-22
Study Completion:2027-12-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05189262

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Admitted to UMMC for cardiac procedure
  2. * Age: \>/=18 y.o TO 75 y.o.
  3. * Undergoing CPB \>1hr for the following surgeries (a) complex cardiac surgery (b) heart valve replacement surgery OR (c) CABG surgery.
  1. * Pregnant
  2. * Non English speaking
  3. * Unable to consent or have Legally Authorized Representative (LAR) assent to study

Contacts and Locations

Study Contact

Paul W Buehler, PhD
CONTACT
14107065171
pbuehler@som.umaryland.edu
Tobi Rowden, RN
CONTACT
4107064061
trowden@som.umaryland.edu

Principal Investigator

Paul Buehler, PhD
PRINCIPAL_INVESTIGATOR
University of Maryland

Study Locations (Sites)

Center for Blood Oxygen Transport and Hemostasis
Baltimore, Maryland, 21201
United States

Collaborators and Investigators

Sponsor: University of Maryland, Baltimore

  • Paul Buehler, PhD, PRINCIPAL_INVESTIGATOR, University of Maryland

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-03-22
Study Completion Date2027-12-01

Study Record Updates

Study Start Date2022-03-22
Study Completion Date2027-12-01

Terms related to this study

Additional Relevant MeSH Terms

  • Cardiopulmonary Bypass
  • Cardiac Surgery
  • Kidney Injury, Acute