Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction

Description

Surgical mesh products, particularly acellular dermal matrices (ADM), are now used by the majority of plastic surgeons to assist with the nearly 100,000 prosthetic breast reconstruction procedures in the United States, despite never being approved by Food and Drug Administration (FDA) for this indication. As surgeons transition to placing breast implants above the chest muscle (pre-pectoral), there has been an increasing reliance on these often expensive mesh products without robust evidence to understand their risks and benefits. Our pilot study is a randomized multi-center trial to evaluate surgical mesh assistance in pre-pectoral tissue expander to breast implant reconstruction to address vital questions for women's public health.

Conditions

Breast Cancer, Breast Implant; Complications, Infection or Inflammation

Study Overview

Study Details

Study overview

Surgical mesh products, particularly acellular dermal matrices (ADM), are now used by the majority of plastic surgeons to assist with the nearly 100,000 prosthetic breast reconstruction procedures in the United States, despite never being approved by Food and Drug Administration (FDA) for this indication. As surgeons transition to placing breast implants above the chest muscle (pre-pectoral), there has been an increasing reliance on these often expensive mesh products without robust evidence to understand their risks and benefits. Our pilot study is a randomized multi-center trial to evaluate surgical mesh assistance in pre-pectoral tissue expander to breast implant reconstruction to address vital questions for women's public health.

Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction

Randomized Feasibility Trial for Mesh in Pre-Pectoral Reconstruction

Condition
Breast Cancer
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of California Los Angeles, Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female patients age 22 to 75 undergoing unilateral or bilateral immediate pre-pectoral reconstruction with tissue expanders
  • * Prophylactic and oncologic mastectomies are both acceptable
  • * Nipple sparing and skin sparing mastectomy techniques are both acceptable
  • * Intraoperative assessment demonstrates unfavorable conditions (ie poor mastectomy skin flap thickness or viability) for immediate pre-pectoral reconstruction in any breast
  • * Bilateral reconstruction patients undergoing contralateral submuscular reconstruction
  • * Direct-to-implant reconstruction
  • * Pregnancy
  • * Delayed reconstruction

Ages Eligible for Study

22 Years to 75 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Michael Delong, MD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

2025-04-30