Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

Description

Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.

Conditions

Major Depressive Disorder

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Study Overview

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Study Details

Study overview

Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

Condition
Major Depressive Disorder
Intervention / Treatment

-

Contacts and Locations

San Francisco

San Francisco VA Medical Center, San Francisco, California, United States, 94121

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * All participants
  • * 18-65 years old
  • * Normal (or corrected to normal) vision
  • * Participants with MDD
  • * Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD
  • * Screened for TMS and MRI safety
  • * On a stable psychiatric medication regime for \> 1 month
  • * Premorbid IQ estimate \< 70
  • * Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
  • * Loss of consciousness \> 30 minutes or any loss of consciousness with neurological sequelae
  • * Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or other physical conditions if they preclude participation in EEG, TMS, or MRI protocols (e.g. peripheral nerve damage, limb paralysis etc.)
  • * Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions
  • * Known claustrophobia
  • * Pregnancy (a pregnancy urine test will be conducted to rule-out pregnancy)
  • * Past or present DSM-5 (SCID-5) 'Schizophrenia Spectrum or Other Psychotic Disorder' diagnosis
  • * Past or present DSM-5 (SCID-5) Bipolar and Related Disorders Diagnosis
  • * Past or present DSM-5 (SCID-5) MDD with psychotic features (mood congruent or mood incongruent)
  • * Past or present DSM-5 (SCID-5) Gambling Disorder

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

San Francisco Veterans Affairs Medical Center,

Susanna L Fryer, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2024-09-30