RECRUITING

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.

Official Title

Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression

Quick Facts

Study Start:2021-10-01
Study Completion:2024-09-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05194098

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * All participants
  2. * 18-65 years old
  3. * Normal (or corrected to normal) vision
  4. * Participants with MDD
  5. * Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD
  6. * Screened for TMS and MRI safety
  7. * On a stable psychiatric medication regime for \> 1 month
  8. * Premorbid IQ estimate \< 70
  9. * Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
  10. * Loss of consciousness \> 30 minutes or any loss of consciousness with neurological sequelae
  11. * Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or other physical conditions if they preclude participation in EEG, TMS, or MRI protocols (e.g. peripheral nerve damage, limb paralysis etc.)
  12. * Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions
  13. * Known claustrophobia
  14. * Pregnancy (a pregnancy urine test will be conducted to rule-out pregnancy)
  15. * Past or present DSM-5 (SCID-5) 'Schizophrenia Spectrum or Other Psychotic Disorder' diagnosis
  16. * Past or present DSM-5 (SCID-5) Bipolar and Related Disorders Diagnosis
  17. * Past or present DSM-5 (SCID-5) MDD with psychotic features (mood congruent or mood incongruent)
  18. * Past or present DSM-5 (SCID-5) Gambling Disorder
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Jason B Hemmerle, MBA
CONTACT
4152214810
jason.hemmerle@ucsf.edu

Principal Investigator

Susanna L Fryer, PhD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

San Francisco VA Medical Center
San Francisco, California, 94121
United States

Collaborators and Investigators

Sponsor: San Francisco Veterans Affairs Medical Center

  • Susanna L Fryer, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-01
Study Completion Date2024-09-30

Study Record Updates

Study Start Date2021-10-01
Study Completion Date2024-09-30

Terms related to this study

Keywords Provided by Researchers

  • Major Depressive Disorder
  • Reward Processing
  • EEG
  • rTMS Neurostimulation
  • dorsal medial prefrontal cortex

Additional Relevant MeSH Terms

  • Major Depressive Disorder