Liver Cancer Prevention Randomized Control Trial

Eligibility Criteria

• 1. Evidence of steatosis (CAP score ≥ 290 by vibration controlled transient elastography) OR Evidence of liver fibrosis (FIB-4 index ≥ 1.6 or fibrosis grade ≥ F2 by vibration controlled transient elastography \[F2 score ≥ 8kPa\]) AND meets one of the following criteria: i. overweight or obese (BMI≥23 in Asians or BMI≥25 in other racial groups), OR ii. presence of type II diabetes mellitus, OR iii. lean/normal weight with presence of at least two metabolic risk abnormalities, OR:
• 1. Waist circumference ≥90/80 cm in Asians or ≥102/88 cm in other racial groups)
• 2. Blood pressure ≥130/85 mmHg or specific drug treatment
• 3. Plasma triglycerides ≥150 mg/dl or specific drug treatment
• 4. Plasma HDL-cholesterol \<40 mg/dl for men and \<50 mg/dl for women, or specific drug treatment
• 5. Prediabetes (fasting glucose levels 100-125 mg/dl , or HbA1c 5.7-6.4% ) iv. AUDIT-C ≥4 for men and ≥3 for women AND AUDIT-10 = 8-15
• 1. chronic HBV (HBsAg+ or taking anti-HBV therapy), or
• 2. chronic HCV (1. detectable HCV RNA \> 4 months or a 2. history of HCV infection and taking anti-HCV therapy)
• 3. At least 18 years old 4. Speak and read English or Spanish 5. Access to smartphone with data plan or Wi-Fi access 6. Willing to receive up to 12 text messages per week
• 1. Pregnant or planning to become pregnant in next 12 months (by self-report)
• 2. Medical contraindications to home-based exercise or low-fat, high-vegetable-and-fruit diet
• 3. Recent or planned surgery that would interfere with home-based exercise or a low-fat, high vegetable and fruit diet
• 4. Current or prior history of primary liver cancer or cancer that is metastatic to the liver
• 5. AUDIT-10 score \>15
• 6. Family or household member already enrolled into study