NextGen - Clinical Implication of Next Generation Sequencing

Description

Recently more advanced techniques, including Polymerase Chain Reaction (PCR) and Next Generation Sequencing (NGS) are available to detect bacteria in urine based on bacterial genomes. Comparing to traditional culture, these techniques have more sensitivity and could potentially be of a great help in patients with Colony Count of less than 10,000 and more than zero.

Conditions

Urinary Tract Infections

Study Overview

Study Details

Study overview

Recently more advanced techniques, including Polymerase Chain Reaction (PCR) and Next Generation Sequencing (NGS) are available to detect bacteria in urine based on bacterial genomes. Comparing to traditional culture, these techniques have more sensitivity and could potentially be of a great help in patients with Colony Count of less than 10,000 and more than zero.

Clinical Implication of Next Generation Sequencing of Urinary Bacteria in Patients With Low Colony Forming Units of Bacteria in Traditional Urine Culture

NextGen - Clinical Implication of Next Generation Sequencing

Condition
Urinary Tract Infections
Intervention / Treatment

-

Contacts and Locations

Winston-Salem

Wake Forest Health Sciences, Winston-Salem, North Carolina, United States, 27157

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female at least 18 years of age
  • * U/C (Urinary Culture) growth of \<10,000 Colony-Forming Units (CFU)
  • * Understanding and acceptance of the need to return for all scheduled follow-up visits
  • * Able to give informed consent
  • * Catheter in use (Foley or suprapubic or intermittent)
  • * Not able to provide clean midstream urine
  • * Antibiotic consumption in the past 2 weeks before signing the consent
  • * Pregnant or Planning to Conceive
  • * Incarcerated

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Wake Forest University Health Sciences,

Majid Mirzazadeh, MD, PRINCIPAL_INVESTIGATOR, Wake Forest Health Sciences

Study Record Dates

2026-06