Primary objective is to assess whether changes in quantitative tumor perfusion parameters after 3 weeks of treatment, as measured by CEUS, can predict initial objective response to therapy, defined by current standard-of-care Secondary objectives are to evaluate if there is an optimal ultrasound imaging modality (CEUS or conventional power Doppler or LEAD ultrasound) or optimal time point to predict initial objective response and to assess the correlation of tumor perfusion parameters with change in overall tumor burden, change in diameter on a per-lesion basis, and with 12-month progression-free survival (PFS).
Solid Tumor
Primary objective is to assess whether changes in quantitative tumor perfusion parameters after 3 weeks of treatment, as measured by CEUS, can predict initial objective response to therapy, defined by current standard-of-care Secondary objectives are to evaluate if there is an optimal ultrasound imaging modality (CEUS or conventional power Doppler or LEAD ultrasound) or optimal time point to predict initial objective response and to assess the correlation of tumor perfusion parameters with change in overall tumor burden, change in diameter on a per-lesion basis, and with 12-month progression-free survival (PFS).
Serial Ultrasound of Solid Tumor Lesions to Detect Early Response to Cancer Immunotherapy
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Stanford, Palo Alto, California, United States, 94305
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18 Years to
ALL
No
Stanford University,
Alice C. Fan, MD, PRINCIPAL_INVESTIGATOR, Stanford University
Jeremy Dahl, Ph.D, PRINCIPAL_INVESTIGATOR, Stanford University
Aya Kamaya, M.D, PRINCIPAL_INVESTIGATOR, Stanford University
2026-02-28