Screening Women With Prior HPV for Anal Neoplasia

Description

The goal of this single arm trial is to prospectively evaluate screening methods for anal cancer precursors in HIV uninfected women with a history of lower genital tract neoplasias and cancers.

Conditions

HPV-related Lower Genital Tract Neoplasias, HPV-related Anal Neoplasias, Early Stage Lower Genital Tract Cancers

Study Overview

Study Details

Study overview

The goal of this single arm trial is to prospectively evaluate screening methods for anal cancer precursors in HIV uninfected women with a history of lower genital tract neoplasias and cancers.

The Effectiveness of Screening Women With Lower Genital Tract Neoplasia or Cancers for Anal Cancer Precursors

Screening Women With Prior HPV for Anal Neoplasia

Condition
HPV-related Lower Genital Tract Neoplasias
Intervention / Treatment

-

Contacts and Locations

New York

Icahn School of Medicine at Mount Sinai, New York, New York, United States, 10029

Charleston

Medical University of South Carolina, Charleston, South Carolina, United States, 29425

Houston

University of Texas M D Anderson Cancer Center, Houston, Texas, United States, 77030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Women with a history of pathologically proven high-grade genital HPV-associated neoplastic disease (cervical intraepithelial neoplasia 2+, vulvar intraepithelial neoplasia 2+, or vaginal intraepithelial neoplasia 2+, or history of non-metastatic cervical, vaginal or vulvar cancer)
  • * Documented HIV seronegativity
  • * Aged 35 years and older
  • * Seen in the Mount Sinai Health System (MSHS) or the Harris Health System (HHS) in Houston
  • * English or Spanish speaking

Ages Eligible for Study

35 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Icahn School of Medicine at Mount Sinai,

Keith Sigel, MD, PhD, MPH, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Elizabeth Chiao, MD, PRINCIPAL_INVESTIGATOR, M.D. Anderson Cancer Center

Ashish Deshmukh, PhD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

2026-11