REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

Description

Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.

Conditions

COVID-19, Critical Illness, ICU Acquired Weakness, PICS, Cardiorespiratory Fitness

Study Overview

Study Details

Study overview

Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.

REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19

Condition
COVID-19
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35233

Durham

Duke University Health System, Durham, North Carolina, United States, 27710

Columbus

The Ohio State University Wexner Medical Center, Columbus, Ohio, United States, 43201

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Primary diagnosis of COVID-19 requiring hospital admission
  • * Discharged or expected to be discharged directly home from the hospital (not to a skilled nursing facility, inpatient rehabilitation center, or long-term acute care hospital)
  • * Able to ambulate with or without a gait aid prior to hospital discharge
  • * Age ≥ 18 years
  • * Hospital discharge \> 60 days unless readmitted to hospital in first 30 days, then 60 day window restarts and new exclusion is last hospital discharge \> 60 days
  • * Not ambulating independently prior to COVID-19 illness (use of a gait aid permitted)
  • * Functional impairment resulting in inability to exercise at baseline
  • * Inability or unwillingness to comply with the study requirements or unable or unwilling to follow coaching via mobile-health iPhone interaction
  • * Any absolute contraindications to exercise, including but not limited to:
  • * Recent (\< 5 days) acute primary cardiac event
  • * Unstable Angina
  • * Uncontrolled dysrhythmias causing symptoms or hemodynamic compromise
  • * Uncontrolled hypertension over 255 mmHg Systolic or 155 diastolic blood pressure
  • * Symptomatic aortic stenosis
  • * Uncontrolled symptomatic heart failure
  • * Acute myocarditis or pericarditis
  • * Suspected or known dissecting aneurysm
  • * Any adverse changes during GXT (i.e., persistent oxygen saturation drop below 88% while on prescribed oxygen therapy or significant hypotension such as mean arterial blood pressure \< 60 mmHg on 2 consecutive readings within 1 minute)
  • * High risk for non-adherence as determined by screening evaluation
  • * Any condition, including cognitive impairment, that, in the judgment of the investigator, precludes participation because it could affect subject safety or ability of subject to complete the study
  • * Pregnant

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Duke University,

Paul Wischmeyer, MD, PRINCIPAL_INVESTIGATOR, Duke Clinical Research Institute

Study Record Dates

2026-11-01