Lifestyle Patterns and Glycemic Control

Description

The goal of the proposed study is to evaluate the feasibility and initial efficacy of stabilizing lifestyle behaviors to improve glucose control and body composition in patients with pre-diabetes. The investigator proposes that following stable lifestyle behaviors will improve patients' glucose control, body composition, and liver fat. The results from this study has the potential to impact clinical practice and patient care.

Conditions

Pre-diabetes

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Study Overview

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Study Details

Study overview

The goal of the proposed study is to evaluate the feasibility and initial efficacy of stabilizing lifestyle behaviors to improve glucose control and body composition in patients with pre-diabetes. The investigator proposes that following stable lifestyle behaviors will improve patients' glucose control, body composition, and liver fat. The results from this study has the potential to impact clinical practice and patient care.

Lifestyle Patterns and Glycemic Control

Lifestyle Patterns and Glycemic Control

Condition
Pre-diabetes
Intervention / Treatment

-

Contacts and Locations

New York

Columbia University Irving Medical Center, New York, New York, United States, 10032

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Pre-diabetic kg/m2 (hemoglobin A1c 5.7-6.9%)
  • * 25 years or older
  • * BMI between 25-39.9 kg/m2
  • * Sleep duration ≥6 hours a night assessed with wrist actigraphy (for 14 nights)
  • * Variable bedtime, SD≥45 minutes.
  • * Chronic Kidney Disease (GFR\<60)
  • * Uncontrolled hypertension (≥160/100 mmHg)
  • * Obstructive Sleep Apnea
  • * Psychiatric or neurological disorder
  • * Prevalent cardiovascular disease
  • * Dyslipidemia (triglycerides≥200 mg/dL)
  • * Medications that affect insulin sensitivity, glucose concentrations, and body weight
  • * Non-day or rotating shift workers
  • * Travel across time zones
  • * Active participation in weight loss program or within past 3 months
  • * Current or past alcohol/drug abuse

Ages Eligible for Study

25 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Columbia University,

Marie-Pierre St-Onge, PRINCIPAL_INVESTIGATOR, Columbia University

Blandine Laferrere, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

2025-06-01