Intravesical LGG VS Saline Bladder Wash RCT

Description

This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI).

Conditions

Spinal Cord Injuries, Neurogenic Bladder

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Study Overview

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Study Details

Study overview

This is the first ever comparative effectiveness study of an antibiotic-sparing novel self-management intervention to prevent complicated urinary tract infection (UTI).

Intravesical Lactobacillus rhamnosusGG Versus Saline Bladder Wash: A Randomized, Controlled, Comparative Effectiveness Clinical Trial

Intravesical LGG VS Saline Bladder Wash RCT

Condition
Spinal Cord Injuries
Intervention / Treatment

-

Contacts and Locations

Washington

MedStar National Rehabilitation Hospital, Washington, District of Columbia, United States, 20010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age ≥18 years;
  • 2. SCI at least 6 months duration;
  • 3. NLUTD (as determined by their SCI physician or urologist);
  • 4. Utilizing intermittent catheterization for bladder management; and
  • 5. Community dwelling (discharged from the acute care setting).
  • 1. Known genitourinary pathology beyond neuropathic bladder (i.e., vesicoureteral reflux, bladder or kidney stones, etc.);
  • 2. Use of prophylactic antibiotics;
  • 3. Instillation of intravesical agents (e.g., gentamycin, saline; or Lactobacillus);
  • 4. Immunodeficiency;
  • 5. Any oral antibiotics within the past 2 weeks;
  • 6. Psychologic or psychiatric conditions influencing the ability to follow instructions;
  • 7. Participation in another study in which results would be confounded;
  • 8. 6 months since prior exposure to intravesical LGG®; and
  • 9. Active cancer (or within 5 years) or active autoimmune disorder

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medstar Health Research Institute,

Suzanne Groah, MD, MSPH, PRINCIPAL_INVESTIGATOR, MedStar National Rehabilitation Hospital

Study Record Dates

2026-12-31