Secretin in Refeeding

Description

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Conditions

Anorexia in Adolescence

Study Overview

Study Details

Study overview

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Secretin Levels in Refeeding-induced Polyuria (Cross Section)

Secretin in Refeeding

Condition
Anorexia in Adolescence
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of California, Los Angeles (UCLA), Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Group 1:
  • * male and female patients
  • * age 13-24 years
  • * diagnosis of restrictive-type anorexia nervosa
  • * hospitalization for nutritional support
  • * \>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
  • * Group 2:
  • * male and female patients
  • * age 13-24 years
  • * diagnosis of restrictive-type anorexia nervosa
  • * hospitalization for nutritional support
  • * \<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)
  • * 5150 hold
  • * Anti-depressant, anti-psychotic, or anticonvulsant medications
  • * Previous hospitalization within the past 6 months
  • * Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
  • * Pregnancy
  • * NG or G-tube feeds after day 2 of hospitalization
  • * \> 10% of nutritional needs from supplemental feeds

Ages Eligible for Study

13 Years to 24 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Study Record Dates

2024-12-31