RECRUITING

Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet on Cellular Zinc

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Conditions

Zinc DeficiencyInflammationMetabolic DiseasesVascular Diseases

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective of the current study is to test the overarching hypothesis that the beef nutritive matrix is uniquely suited to direct dietary zinc to cellular compartments for improved metabolic function, leading to a greater effect on health outcomes. Specifically, whether beef, as a component of a healthy meal, will promote the absorption of zinc into cells, where the zinc will have greater effects on zinc-dependent metabolic processes supporting cardiovascular health. To maximize the observability of these beef-related effects, individuals who are 55- to 70-year-old who generally have a higher risk of zinc deficiency and cardiovascular disease will be enrolled.

Official Title

Effects of Daily Beef Intake, as a Component of a Heart-Healthy Diet, on Cellular Zinc Status and Vascular Function in Older Adults

Quick Facts

Study Start:2022-10-01
Study Completion:2026-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05236374

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male or postmenopausal female 55-70 years of age
  2. * Women: lack of menses for at least two years.
  3. * Subject is willing and able to comply with the study protocols.
  4. * Subject is willing to participate in all study procedures
  5. * Self-reported stable dose of prescribed medications for a minimum of 6 months
  6. * BMI 18.5 - 29.9 kg/m2
  1. * Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
  2. * Prescribed metaformin, statins or medications known to interfere with zinc, protein, or lipid metabolism
  3. * Vegan, Vegetarians, food faddists or those consuming a non-traditional diet (e.g. Adkins, Keto, Paleo, etc.)
  4. * Fruit consumption ≥ 3 cups/day
  5. * Regular consumption of strawberries (2-3 servings/week)
  6. * Vegetable consumption ≥ 4 cups/day
  7. * Coffee/tea ≥ 3 cups/day
  8. * Dark chocolate ≥ 3 oz/day
  9. * Alcohol intake greater than 2 drinks in a day for men, or 1 drink in a day for women.
  10. * Self-reported restriction of physical activity due to a chronic health condition
  11. * Self-reported chronic/routine high intensity exercise
  12. * Self-reported diabetes
  13. * Blood pressure ≥ 140/90 mm Hg
  14. * Self-reported renal or liver disease
  15. * Self-reported heart disease, which includes cardiovascular events and stroke
  16. * Peripheral artery disease Raynaud's syndrome or disease
  17. * Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT
  18. * Self-reported cancer within past 5 years
  19. * Self-reported malabsorption
  20. * Unwillingness to stop any supplement use six weeks prior to study initiation, including multivitamin/mineral, powders, herbal, plant or botanical, pro- and prebiotics, and oil supplements.
  21. * Smoking, vaping, cannabis use
  22. * Current enrollee in a clinical research study.

Contacts and Locations

Study Contact

Roberta R Holt, PhD
CONTACT
15304005952
rrholt@ucdavis.edu
Andrew Hall, PhD
CONTACT
aghall@ucdavis.edu

Principal Investigator

Carl L Keen, PhD
PRINCIPAL_INVESTIGATOR
Distinguished Professor Emeritus of Nutrition

Study Locations (Sites)

University of California, Davis; Department of Nutrition
Davis, California, 95616
United States

Collaborators and Investigators

Sponsor: University of California, Davis

  • Carl L Keen, PhD, PRINCIPAL_INVESTIGATOR, Distinguished Professor Emeritus of Nutrition

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-01
Study Completion Date2026-12-31

Study Record Updates

Study Start Date2022-10-01
Study Completion Date2026-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Zinc Deficiency
  • Inflammation
  • Metabolic Diseases
  • Vascular Diseases