RECRUITING

Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to investigate whether transcranial direct-current stimulation (tDCS) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) regions. Also to evaluate whether the changes in the fractional anisotropy (FA) of the UF tract are associated with changes of clinical symptoms of anhedonia and finally to investigate the moderation role of simulated electric fields (EFs) in an association between FA of the UF and symptoms of anhedonia.

Official Title

Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression

Quick Facts

Study Start:2022-10-06
Study Completion:2025-12-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05240352

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * diagnosis of Bipolar Disorder and clinically significant anhedonia
  2. * mild symptoms of depression
  1. * substance abuse/dependence and any use of drugs (except alcohol or nicotine) in the previous month of the baseline assessment
  2. * participants with personality disorder that would interfere with study participation according to clinical judgment
  3. * previous neurological conditions (epilepsy, traumatic brain injury, stroke, etc)
  4. * any severe, life-threatening non-psychiatric medical condition
  5. * specific contraindications for tDCS (metallic plates in the head)
  6. * Participants identified as acutely suicidal or severely agitated

Contacts and Locations

Study Contact

Jair C Soares, MD,PhD
CONTACT
(713) 486-2507
Jair.C.Soares@uth.tmc.edu
Alexandre P Diaz, MD,PhD
CONTACT
(713) 486-2700
Alexandre.PaimDiaz@uth.tmc.edu

Principal Investigator

Jair C Soares, MD,PhD
PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston

Study Locations (Sites)

The University of Texas Health Science Center at Houston
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center, Houston

  • Jair C Soares, MD,PhD, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center, Houston

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-10-06
Study Completion Date2025-12-01

Study Record Updates

Study Start Date2022-10-06
Study Completion Date2025-12-01

Terms related to this study

Keywords Provided by Researchers

  • bipolar depression

Additional Relevant MeSH Terms

  • Anhedonia