Mapping and Quantifying Lymphatic Drainage of the Arm's Alternate Pathway

Description

Using indocyanine green (ICG) lymphography and lymphoscintigraphy with SPECT/CT imaging, the aim is to evaluate the anatomy of the lymphatic system pathway in two separate populations: healthy female volunteers and women with a history of breast cancer who did not develop lymphedema.

Conditions

Lymphatic System

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Study Overview

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Study Details

Study overview

Using indocyanine green (ICG) lymphography and lymphoscintigraphy with SPECT/CT imaging, the aim is to evaluate the anatomy of the lymphatic system pathway in two separate populations: healthy female volunteers and women with a history of breast cancer who did not develop lymphedema.

Variable Anatomy and Function of the Arm's Alternate Lymphatic Pathway

Mapping and Quantifying Lymphatic Drainage of the Arm's Alternate Pathway

Condition
Lymphatic System
Intervention / Treatment

-

Contacts and Locations

Boston

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female
  • * History of breast cancer treatment including ALND - defined by removal of \>=10 lymph nodes - more than 2 years before study participation
  • * Ability to understand the protocol and willingness to participate
  • * At least 18 years of age
  • * Prior history of bilateral lymph node surgery
  • * Prior history of other surgical procedures of the affected upper extremity besides the axillary management for breast cancer treatment
  • * Prior history of chronic inflammatory conditions (e.g. rheumatoid arthritis)
  • * Prior history of filarial infections
  • * Prior history of lymphedema
  • * Patient-reported pregnancy
  • * Patients who are breastfeeding
  • * Iodine allergy
  • * Prior history of upper extremity deep vein thrombosis
  • * Prior history of congestive heart failure
  • * Prior history of venous thoracic outlet syndrome
  • * Current active cancer

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Beth Israel Deaconess Medical Center,

Dhruv Singhal, MD, PRINCIPAL_INVESTIGATOR, Beth Israel Deaconess Medical Center

Study Record Dates

2025-08