Chemoradiotherapy With Targeted Immunotherapy in Pediatric Lymphoma

Description

The addition of targeted immunotherapy will be safe and well tolerated and facilitate the reduction of anthracycline exposure while preserving lymphoma disease control in children, adolescents and young adults (CAYA) with mature B-cell non-Hodgkin lymphoma (MB-NHL) and classical Hodgkin lymphoma (cHL).

Conditions

Non-hodgkin Lymphoma, Hodgkin Lymphoma

Study Overview

Study Details

Study overview

The addition of targeted immunotherapy will be safe and well tolerated and facilitate the reduction of anthracycline exposure while preserving lymphoma disease control in children, adolescents and young adults (CAYA) with mature B-cell non-Hodgkin lymphoma (MB-NHL) and classical Hodgkin lymphoma (cHL).

Reducing the Burden of Oncologic Chemoradiotherapy And Radiation Exposure From Diagnostic Imaging by Utilizing Targeted Immunotherapy in Children, Adolescents and Young Adults With Lymphoma

Chemoradiotherapy With Targeted Immunotherapy in Pediatric Lymphoma

Condition
Non-hodgkin Lymphoma
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama, Birmingham, Alabama, United States, 35233

Gainesville

University of Flordia, Gainesville, Florida, United States, 32610

Valhalla

New York Medical College, Valhalla, New York, United States, 10595

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Newly diagnosed patients with histologically or cytologically proven newly diagnosed MB-NHL or cHL according to WHO Classification who meet the following criteria are eligible:
  • * Adequate organ function
  • * Primary mediastinal B-cell lymphoma (PMBL)
  • * T-cell/histiocyte-rich large B-cell lymphoma
  • * Gray zone lymphoma
  • * Follicular lymphoma
  • * Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)
  • * Posttransplant lymphoproliferative lymphoma (PTLD)

Ages Eligible for Study

3 Years to 39 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

New York Medical College,

Mitchell Cairo, MD, PRINCIPAL_INVESTIGATOR, New York Medical Center

Study Record Dates

2028-06-30