Cortical Excitability in Cyclic Vomiting Syndrome

Description

This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).

Conditions

Cyclic Vomiting Syndrome

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Study Overview

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Study Details

Study overview

This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).

Cortical Excitability in Cyclic Vomiting Syndrome

Cortical Excitability in Cyclic Vomiting Syndrome

Condition
Cyclic Vomiting Syndrome
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States, 15232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * diagnosis of CVS
  • * history of CVS (for healthy control population only)
  • * psychosis or altered cognitive status
  • * history of head injury, metal in the skull, stroke, or a history of seizures
  • * implantable devices, such as a pacemaker or nerve stimulator
  • * current use of the following medications or use of substances which are known to lower the seizure threshold: clozapine (Clozaril), chlorpromazine (Thorazine), amphetamines or methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or 3 or more alcoholic drinks per day
  • * pregnancy

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Pittsburgh,

David J Levinthal, MD PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2025-06