This is an 8-week, double-blind, randomized placebo-controlled trial of the efficacy of a combination of extended-release naltrexone (XR-NTX) and extended-release buprenorphine (XR-BUP) compared to matched placebo injections (PBO-Inj) for the treatment of cocaine use disorder (CUD).
Cocaine Use Disorder
This is an 8-week, double-blind, randomized placebo-controlled trial of the efficacy of a combination of extended-release naltrexone (XR-NTX) and extended-release buprenorphine (XR-BUP) compared to matched placebo injections (PBO-Inj) for the treatment of cocaine use disorder (CUD).
Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder (CURB-2)
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University of Alabama at Birmingham, Birmingham, Alabama, United States, 35209
University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States, 72205
UCLA Vine Street Clinic, Los Angeles, California, United States, 90038
Center on Substance Use and Health (CSUH), San Francisco, California, United States, 94102
Cove Behavioral Health, Tampa, Florida, United States, 33605
University of Illinois at Chicago, Chicago, Illinois, United States, 60608
University of Chicago, Chicago, Illinois, United States, 60637
Mountain Manor Treatment Center, Baltimore, Maryland, United States, 21229
Berman Center for Outcomes and Clinical Research at Hennepin Healthcare, Minneapolis, Minnesota, United States, 55404
Addictions Institute of Mount Sinai, New York, New York, United States, 10029
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to 65 Years
ALL
No
University of Texas Southwestern Medical Center,
Madhukar Trivedi, MD, PRINCIPAL_INVESTIGATOR, UT Southwestern Medical Center
2026-09