Mode of Exercise and Bone Biomarkers in Older Veterans

Description

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.

Conditions

Aging, Musculoskeletal Diseases, Osteoporosis

Talk to us

Study Overview

On this page

Study Details

Study overview

Adults are often encouraged to exercise to maintain or improve bone health. However, there is evidence that exercise does not always lead to increases in bone mass, and exercise could lead to bone loss under certain conditions. Endurance exercise can increase bone resorption following an exercise bout, which may explain why bone does not always favorably adapt to exercise, but it is unclear if this also happens with resistance exercise. Further, it is not known how exercise training influences blood markers of bone resorption for either endurance or resistance exercise. The purpose of this study is to determine 1) if resistance exercise causes a similar increase in bone resorption as endurance exercise; and 2) if exercise training influences the increase in bone resorption following exercise for both endurance and resistance exercise.

Anabolic Versus Catabolic Skeletal Effects of Endurance or Resistance Exercise in Older Veterans

Mode of Exercise and Bone Biomarkers in Older Veterans

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

Aurora

Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy older (60+ y) Veteran women and men in the Denver Metro Area
  • * Normally active (e.g., recreational cycling or walking exercise)
  • * Impaired renal function, defined as an eGRF of \<60 mL/min/1.73m2
  • * Hepatobiliary disease, defined as liver function tests (AST, ALT) \>1.5 times the upper limit of normal
  • * Thyroid dysfunction, defined as an ultrasensitive thyroid stimulating hormone (TSH) \<0.5 or \>5.0 mU/L
  • * Serum Ca \<8.5 or \>10.3 mg/dL
  • * Serum 25(OH)D \<20 ng/mL
  • * Uncontrolled hypertension, defined as resting systolic blood pressure (BP) \>150 mmHg or diastolic BP \>90 mmHg;
  • * History of type 1 or type 2 diabetes
  • * Cardiovascular disease, defined as subjective or objective indicators of ischemic heart disease (e.g., angina, ST segment depression) or serious arrhythmias at rest or during the graded exercise test (GXT). Volunteers who have a positive GXT can be re-considered after follow-up evaluation, which must include diagnostic testing (e.g., stress echocardiogram or thallium stress test) with interpretation by a cardiologist
  • * Anemia, defined as a serum hemoglobin \<12.1 g/dL for women and \<14.3 g/dL for men
  • * Fracture in the past 6 months
  • * Current diagnosis or symptoms of COVID-19

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

VA Office of Research and Development,

Sarah J Wherry, PhD, PRINCIPAL_INVESTIGATOR, Rocky Mountain Regional VA Medical Center, Aurora, CO

Study Record Dates

2027-03-31