Endoscopic Evidence of Maintenance of Healing With Oral NEXIUM in Patients 1 to 11 Years Old With Erosive Esophagitis.

Eligibility Criteria

• 1. Patient must be 1 to 11 years of age
• 2. Patients must have a clinical history of GERD for at least 3 months before the start of study
• 3. For the healing phase: Patients must have confirmed presence of EE at endoscopy performed within one week of the start of the healing phase.
• 4. For the maintenance phase: Patients must have completed the healing phase and have endoscopy-verified healed EE at the 8-week endoscopy visit.
• 5. Patients must weigh ≥ 10 kg.
• 6. Patients may be male or female.
• 7. All postmenarcheal female patients must have a negative pregnancy test (urine) before starting treatment.
• 8. Sexually active patients must be abstinent or maintain effective contraception from informed consent day up to the last day of study intervention.
• 9. Patient's guardian must be capable of giving signed informed consent
• 1. Presence of other diseases, such as severe heart, lung, liver, renal, blood, or neurological disease or similar
• 2. Significant clinical illness within 4 weeks prior to the start of treatment
• 3. Any conditions that are predicted to require a surgery during the study period (from the day of informed consent to the day of the last scheduled visit)
• 4. Previous total gastrectomy
• 5. Anticipated need for concomitant therapy with PPIs (except for the IMPs), H2-receptor antagonists and other drugs outlined in EC#5 after enrollment in this study
• 6. Participation in another clinical study with an IMP administered in the last 4 weeks before enrollment.
• 7. Patients with a known hypersensitivity to NEXIUM, or any other PPI, or any of the excipients of the product
• 8. Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site).
• 9. Judgment by the Investigator that the patient should not participate in the study if the patient or guardian is unlikely to comply with study procedures, restrictions, and requirements
• 10. Previous screening, or enrollment and randomization in the present study