Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Description

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Conditions

Fibromyalgia, Rheumatoid Arthritis

Study Overview

Study Details

Study overview

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder that afflicts up to 4% of the general population. The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome. Rheumatoid arthritis (RA) is characterized by polyarthritis and pain from inflamed tissues, consistent with nociceptive pain. FM and RA patients may utilize overlapping pain mechanisms resulting in nociceptive and nociplastic pain.

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Pain Processing in Inflammatory and Non-Inflammatory Chronic Pain Syndromes

Condition
Fibromyalgia
Intervention / Treatment

-

Contacts and Locations

Gainesville

University of Florida, Gainesville, Florida, United States, 32610

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 18-70
  • * Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM
  • * Fulfills the 2010 ACR-EULAR classification criteria for RA
  • * Healthy volunteers: No significant pain/fatigue/depression/anxiety.
  • * Diabetes
  • * Cancer
  • * Advanced liver, kidney or cardiovascular disease
  • * Neuropathic pain

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Florida,

Roland Staud, M.D., PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2026-02-28