nCCR for Chemotherapy Related Cognitive Impairment Randomized Study

Eligibility Criteria

• * between 35 and 80 years of age
• * have been diagnosed with noninvasive or invasive breast cancer
• * have undergone treatment with systemic chemotherapy within the last 1- 8 years
• * endorse persistent CRCI subjective complaints
• * have no active unstable medical condition
• * fluent in and able to read English.
• * any active neurologic or untreated/non-remitted psychiatric disease, (e.g. active major depression or another major psychiatric disorder as described in DSM-5)
• * clinically significant cognitive impairment identified on cognitive screening, diagnosis of mild cognitive impairment or dementia
• * history of significant head trauma followed by persistent neurologic deficits
• * history of alcohol or substance abuse or dependence within the past 2 years (DSM-5 criteria)
• * any significant systemic illness or unstable medical condition which could lead to difficulty complying with the protocol
• * Use of any investigational drugs within 30 days or 5 half-lives, whichever is longer, prior to screening
• * red-green color blindness
• * Use of certain CNS active medications (e.g. antidepressants) will be permitted, provided dosing has been stable for at least 3 months.