RECRUITING

Ocular Pathogen and Transcriptome Investigation Using Comprehensive Sequencing

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a multi-center randomized controlled evaluator-masked trial designed to compare metagenomic deep sequencing (MDS) versus standard of care testing for improvement of outcomes for intraocular infections. Patients with presumed intraocular infections who meet the eligibility criteria will be randomized to receive MDS testing results or not to receive MDS testing results. All patients will receive standard-of-care testing to guide management. Enrolled patients will be followed at week 2, week 3-6 (randomization visit), and at 4 weeks after the randomization visit. The proportions of patients who received the appropriate therapy and the proportions of patients with improved outcome will be compared between arms. Patient quality of life, MDS performance, and the provider certainly of belief will be collected.

Official Title

Ocular Pathogen and Transcriptome Investigation Using Comprehensive Sequencing

Quick Facts

Study Start:2022-06-06
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05286203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Presumed infectious anterior uveitis, or intermediate uveitis, or posterior uveitis, or panuveitis
  2. * Presumed post-operative endophthalmitis
  3. * Unilateral or bilateral
  4. * 18 years and older
  1. * Insufficient specimen for MDS
  2. * Age \< 18 years of age
  3. * Pregnancy
  4. * Unable to consent

Contacts and Locations

Study Contact

Jessica Shantha, MD
CONTACT
(415) 476-1442
Jessica.shantha@ucsf.edu
Thuy Doan, MD, PhD
CONTACT
415-476-6939

Principal Investigator

Thuy Doan, MD, PhD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of California San Francisco (UCSF)
San Francisco, California, 94158
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Thuy Doan, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-06-06
Study Completion Date2026-12

Study Record Updates

Study Start Date2022-06-06
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • Uveitis
  • Metagenomic deep sequencing
  • Intraocular infection
  • MDS

Additional Relevant MeSH Terms

  • Uveitis
  • Infectious Disease