RECRUITING

Neuroplasticity in Parkinson's Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes to the emergence and expression of PD motor and non-motor signs. Neurophysiological biomarkers derived from this work may be important for the early detection and prediction of progression of disease. They can also provide the means to assess the efficacy of interventions designed to prevent or slow disease progression.

Official Title

Plasticity of Motor Systems in Early Stage Parkinson's Disease

Quick Facts

Study Start:2021-03-01
Study Completion:2028-11-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05286736

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of idiopathic PD, as determined by a movement disorders neurologist in accordance with the PD Society Brain Bank diagnostic criteria
  2. * Not receiving levodopa or dopamine agonist to treat PD (at baseline)
  3. * Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters Healthy Controls
  4. * Age- (+/- 3 years) and sex-matched to participants with PD
  5. * Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters
  1. * Dementia diagnosis and/or a University of California Brief Assessment of Capacity to Consent (UBACC) score and MacCAT-CR score indicating impaired capacity to consent
  2. * History of musculoskeletal disorders that significant affect movement of lower or upper limbs as determined at the time of enrollment
  3. * History of bipolar disorder, post-traumatic stress disorder or major depressive disorder
  4. * Other significant neurological disorders that may affect participation or performance in the study
  5. * Implanted DBS or other neurosurgeries to treat PD
  6. * Pregnancy
  7. * History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury
  8. * Intracranial metallic or magnetic devices (e.g. cochlear implant, deep brain stimulator)
  9. * Pacemaker or any implanted device
  10. * History of surgery on blood vessels, brain, or heart
  11. * Unexplained, recurring headaches or concussion within the last six months
  12. * Severe hearing impairment

Contacts and Locations

Study Contact

Colum MacKinnon, PhD
CONTACT
612-625-5993
cmackinn@umn.edu
Madison Aasen
CONTACT
612-505-8325
aasen056@umn.edu

Study Locations (Sites)

University of Minnesota
Minneapolis, Minnesota, 55455
United States

Collaborators and Investigators

Sponsor: University of Minnesota

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-03-01
Study Completion Date2028-11-09

Study Record Updates

Study Start Date2021-03-01
Study Completion Date2028-11-09

Terms related to this study

Keywords Provided by Researchers

  • Parkinson's

Additional Relevant MeSH Terms

  • Parkinson
  • Parkinson Disease