RECRUITING

Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

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Conditions

Primary Ciliary DyskinesiaNasal Nitric Oxide test

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

this study is aiming at learning more about primary ciliary dyskinesia (PCD) and tests that are used to diagnose this condition. One purpose of this study is to measure the level of nitric oxide in the nasal passages and examine how often the results correlate with other tests currently done to make the diagnosis.

Official Title

Use of Nasal Nitric Oxide Testing in Improving Primary Ciliary Dyskinesia Clinical Care

Quick Facts

Study Start:2021-06-14
Study Completion:2025-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05287022

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:2 Years to 21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * • Individuals who are diagnosed with Primary Ciliary Dyskinesia OR
  2. * Individuals undergoing PCD diagnostic testing (ciliary biopsy, PCD genetic testing) or concern based on clinical symptoms (at least two of the following):
  3. * Neonatal respiratory distress
  4. * Organ laterality defects
  5. * Year-round cough starting in first year of life or bronchiectasis on chest CT
  6. * Year-round nasal congestion starting in first year of life or pansinusitis
  7. * Multiple ear infections in the first two years of life with sequelae (e.g. ear tubes, chronic effusion, abnormal audiological exam)
  8. * Ability to provide consent for participation in study by the participants or guardian
  9. * Ability to perform the test
  10. * Age \>= 2 years of age
  1. * • Individuals who are unable to understand the requirements of the study.
  2. * Individuals (or guardians) who are unwilling to provide consent.
  3. * Individuals who are unable to complete the testing
  4. * Recent history of sinus surgery (within four weeks) or bloody nose (within one week) of testing (they can be included at a later date)
  5. * Patients who are currently being treated (within one week) with antibiotics for sinusitis or respiratory symptoms (they can be included at a later date)
  6. * Age \<2 years of age

Contacts and Locations

Study Contact

Zena Ghazala, MD
CONTACT
5013641006
zbghazala@uams.edu

Study Locations (Sites)

Arkansas Children's Hospital
Little Rock, Arkansas, 72202
United States

Collaborators and Investigators

Sponsor: Arkansas Children's Hospital Research Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-06-14
Study Completion Date2025-06

Study Record Updates

Study Start Date2021-06-14
Study Completion Date2025-06

Terms related to this study

Keywords Provided by Researchers

  • Nasal Nitric Oxide test

Additional Relevant MeSH Terms

  • Primary Ciliary Dyskinesia